INT121666

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 11.62
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp1) mitochondrion (Ucp1) transmembrane transport (Ucp1)
Anatomy Link Frequency
fat 2
sympathetic 2
Ucp1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 32 99.38 Very High Very High Very High
Clonidine 2 90.04 High High
Glutamate 10 88.00 High High
tolerance 39 79.12 Quite High
headache 1 69.96 Quite High
Dopamine 1 61.92 Quite High
Bile 5 7.92 Low Low
anesthesia 11 7.68 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
fibrosis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 564 100.00 Very High Very High Very High
Cancer 470 98.72 Very High Very High Very High
Insulin Resistance 51 93.72 High High
Diabetes Mellitus 45 89.52 High High
Metabolic Syndrome 33 89.00 High High
Parkinson's Disease 4 86.04 High High
Hyperlipidemia 10 85.16 High High
Hypoxia 170 84.40 Quite High
Nash(non-alcoholic Steatohepatitis) 27 83.52 Quite High
Fatty Liver 69 83.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, several studies have shown that _3-adrenoreceptor agonists and some dietary constituents induce expression of UCP1 not only in BAT, but also in WAT [16–18].
Positive_regulation (induce) of Gene_expression (expression) of UCP1 associated with obesity and agonist
1) Confidence 0.67 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.59 Pain Relevance 0.09
BAT is a thermogenic organ in which increased expression of UCP1 decreases mitochondrial energy efficiency, leading to the generation of heat [17].
Positive_regulation (increased) of Gene_expression (expression) of UCP1
2) Confidence 0.57 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0 Pain Relevance 0
To accomplish this, we overexpressed the mitochondrial uncoupling protein 1 (UCP1), which can dissipate the proton gradient across the inner mitochondrial membrane without generating ATP.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of UCP1
3) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737639 Disease Relevance 0.19 Pain Relevance 0
In conclusion, we found that a diet supplemented with BOF inhibited the visceral fat accumulation in high-fat diet-fed mice, and that BOF induced gene expression of UCP1, which regulates energy metabolism in WAT.
Positive_regulation (induced) of Gene_expression (expression) of UCP1 in fat associated with obesity
4) Confidence 0.49 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.29 Pain Relevance 0.15
The expression of UCP-1 mRNA was significantly increased in WAT in the HF + BOF group, but there was little expression of UCP-1 mRNA in the BD, HF, or HF + DAI groups (Fig. 3B).
Positive_regulation (increased) of Gene_expression (expression) of UCP-1 mRNA associated with obesity
5) Confidence 0.49 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.21 Pain Relevance 0.04
However, if the expression of UCP1 can be activated in tissues other than BAT by Kampo ingredients, this could constitute a good therapy for obesity.
Positive_regulation (activated) of Gene_expression (expression) of UCP1 associated with obesity
6) Confidence 0.49 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.27 Pain Relevance 0.08
Indeed, UCP1 expression in WAT can lead to an increase in energy expenditure via the generation of heat.
Positive_regulation (increase) of Gene_expression (expression) of UCP1 associated with obesity
7) Confidence 0.49 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.57 Pain Relevance 0.08
Isoproterenol increased Ucp1 expression in brown fat, supporting the notion that there was an increase in sympathetic tone following this treatment (Fig. 2 F).
Positive_regulation (increased) of Gene_expression (expression) of Ucp1 in sympathetic
8) Confidence 0.43 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.13 Pain Relevance 0.18
Addition of oligomycin had little effect on UCP1 overexpressing cells, while it decreased oxygen consumption in control cells (figure 3B).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of UCP1
9) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737639 Disease Relevance 0.36 Pain Relevance 0
Conversely, expression of the mitochondrial uncoupling protein 1 (UCP1) increased oxygen consumption and decreased tumor growth.
Positive_regulation (increased) of Gene_expression (expression) of UCP1 associated with cancer
10) Confidence 0.38 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2737639 Disease Relevance 0.93 Pain Relevance 0
Conversely, expression of the mitochondrial uncoupling protein 1 (UCP1) increased oxygen consumption and decreased tumor growth.
Positive_regulation (increased) of Gene_expression (expression) of uncoupling protein 1 associated with cancer
11) Confidence 0.33 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2737639 Disease Relevance 0.93 Pain Relevance 0
To accomplish this, we overexpressed the mitochondrial uncoupling protein 1 (UCP1), which can dissipate the proton gradient across the inner mitochondrial membrane without generating ATP.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of uncoupling protein 1
12) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737639 Disease Relevance 0.19 Pain Relevance 0
Phosphatase inhibitors induce PPAR-gamma phosphorylation and UCP-1 expression leading to an increase in thermogenesis and reduction in appetite.
Positive_regulation (leading) of Gene_expression (expression) of UCP-1
13) Confidence 0.05 Published 2004 Journal Rev Med Univ Navarra Section Abstract Doc Link 15382615 Disease Relevance 1.02 Pain Relevance 0.15
UCP gene expression is increased in hepatic steatosis and evidence supports a role for UCP3 in fatty acid metabolism by exporting fatty acid anions, and thus maintaining mitochondria CoA levels [82].
Positive_regulation (increased) of Gene_expression (expression) of UCP gene
14) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.92 Pain Relevance 0

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