INT12168

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.90
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ggt1) aging (Ggt1) transferase activity, transferring acyl groups (Ggt1)
Anatomy Link Frequency
epithelial cells 1
Ggt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 2 99.98 Very High Very High Very High
Paracetamol 15 96.80 Very High Very High Very High
Bile 11 89.72 High High
ketamine 1 87.60 High High
anesthesia 1 86.68 High High
tolerance 30 40.32 Quite Low
headache 6 14.96 Low Low
abdominal pain 16 5.00 Very Low Very Low Very Low
nud 14 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 2 99.36 Very High Very High Very High
Disorder Of Lipid Metabolism 20 95.60 Very High Very High Very High
Hepatotoxicity 10 93.00 High High
Toxicity 2 76.88 Quite High
Nephrotoxicity 5 75.00 Quite High
Crystal Associated Disease 2 68.80 Quite High
Hypertension 2 63.92 Quite High
Cardiovascular Disease 2 62.80 Quite High
Necrosis 1 62.12 Quite High
Metabolic Syndrome 2 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This stimulation was abolished by pretreatment of the animals with inhibitors of GGT.
Negative_regulation (inhibitors) of GGT
1) Confidence 0.57 Published 1986 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2881787 Disease Relevance 0 Pain Relevance 0.10
Hepatic gamma glutamyl transpeptidase activity, high in the fetus, declined to adult levels by day 7 (0.03 mumol/mg protein).
Negative_regulation (declined) of gamma glutamyl transpeptidase
2) Confidence 0.51 Published 1994 Journal Hepatology Section Abstract Doc Link 7910575 Disease Relevance 0 Pain Relevance 0.52
Cell killing was significantly reduced by inhibition of gamma-glutamyl transpeptidase with Acivicin. p-Aminophenol was also toxic to renal epithelial cells.
Negative_regulation (inhibition) of transpeptidase in epithelial cells
3) Confidence 0.47 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1631900 Disease Relevance 0.34 Pain Relevance 0.22
Acetaminophen induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP) and decrease in total protein.
Negative_regulation (decrease) of GGTP associated with glutamate and paracetamol
4) Confidence 0.43 Published 2009 Journal Pak J Pharm Sci Section Abstract Doc Link 19168428 Disease Relevance 0.26 Pain Relevance 0.46
Acetaminophen induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP) and decrease in total protein.
Negative_regulation (decrease) of transpeptidase associated with glutamate and paracetamol
5) Confidence 0.37 Published 2009 Journal Pak J Pharm Sci Section Abstract Doc Link 19168428 Disease Relevance 0.26 Pain Relevance 0.47
A decrease in GGTP and uric acid levels were observed in test versus control groups at V2 and V3, but statistically significant only at V2 (Wilcoxon test; p = 0.0284, ANOVA; p = 0.0316, respectively).
Negative_regulation (decrease) of GGTP
6) Confidence 0.17 Published 2009 Journal Nutr J Section Body Doc Link PMC2657159 Disease Relevance 0.51 Pain Relevance 0
The GGTP levels were statistically lower in the PGX group compared to controls.
Negative_regulation (lower) of GGTP
7) Confidence 0.12 Published 2009 Journal Nutr J Section Body Doc Link PMC2657159 Disease Relevance 0.54 Pain Relevance 0

General Comments

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