INT121682

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 5.09
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A5) oxidoreductase activity (CYP3A5) endoplasmic reticulum (CYP3A5)
Anatomy Link Frequency
liver 1
alveolar macrophages 1
lung 1
CYP3A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 6 96.92 Very High Very High Very High
imagery 1 84.44 Quite High
Versed 14 83.28 Quite High
abdominal pain 1 81.36 Quite High
methotrexate 1 78.16 Quite High
lidocaine 7 74.32 Quite High
Dextromethorphan 1 65.52 Quite High
carbamazepine 1 62.56 Quite High
alcohol 1 49.84 Quite Low
Nicotine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 408 99.84 Very High Very High Very High
Toxicity 13 96.40 Very High Very High Very High
Lung Cancer 36 87.64 High High
Ileus 1 84.72 Quite High
Intestinal Pseudo-obstruction 2 83.20 Quite High
Constipation 1 82.52 Quite High
Abdominal Pain 1 81.36 Quite High
Epstein-barr Virus 1 74.52 Quite High
Pulmonary Disease 18 74.24 Quite High
Asthma 12 70.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further explore this issue, we compared the kinetics of product formation for eight different substrates, using heterologously expressed CYP3A4 and CYP3A5 and phenotyped human liver microsomes.
Gene_expression (expressed) of CYP3A5 in liver
1) Confidence 0.73 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 15383492 Disease Relevance 0 Pain Relevance 0.18
Ritonavir is a potent CYP3A5 isoenzyme and P-gp inhibitor.
Gene_expression (isoenzyme) of CYP3A5
2) Confidence 0.63 Published 2009 Journal Pharm World Sci Section Abstract Doc Link 19757141 Disease Relevance 0.71 Pain Relevance 0.43
In smokers, expression of CYP1A1 (p < 0.05), CYP1B1 (p < 0.001), and CYP2C9 (p < 0.05) was increased (p < 0.05) compared with non-smokers, and there was a trend toward increased expression of CYP3A5 (p = 0.0545; Figure 1); however, the expression of CYP2J2 was significantly (p < 0.05) repressed.
Gene_expression (expression) of CYP3A5 associated with nicotine addiction
3) Confidence 0.52 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.73 Pain Relevance 0
Furthermore, within different lung tissue compartments, we observed opposite effects in expression of certain genes (i.e., CYP3A5, EPHX1) for smokers, but these were independent of the sex.
Gene_expression (expression) of CYP3A5 in lung associated with nicotine addiction
4) Confidence 0.40 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.50 Pain Relevance 0.04
Previously, Hukkanen et al. (2003) demonstrated decreased CYP3A5 expression in alveolar macrophages of smokers.
Gene_expression (expression) of CYP3A5 in alveolar macrophages associated with nicotine addiction
5) Confidence 0.40 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.94 Pain Relevance 0
Expression of CYP1A1 (p < 0.01), CYP1B1 (p < 0.001), and CYP2S1 (p < 0.001) was higher in BAL cells from smokers compared with those of nonsmokers (Figure 1), whereas expression of CYP2B6/7 (p < 0.01) and CYP3A5 (p < 0.001) was lower; expression of CYP2A6/7, CYP2E1, CYP2C9, CYP2J2, and FMO5 was not altered.
Gene_expression (expression) of CYP3A5 associated with nicotine addiction
6) Confidence 0.40 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.75 Pain Relevance 0
Gene expression of CYP1A1, CYP1B1, CYP2S1, GSTP1, and EPHX1 was induced in bronchoalveolar lavage cells of smokers, whereas expression of CYP2B6/7, CYP3A5, and UGT2A1 was repressed.
Gene_expression (expression) of CYP3A5 associated with nicotine addiction
7) Confidence 0.40 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1665420 Disease Relevance 0.55 Pain Relevance 0
We now extend the findings of Hukkanen et al. (2003) to BBs and report a trend toward increased CYP3A5 expression in smokers (p < 0.0545), which could result in local metabolic activation of carcinogens.
Gene_expression (expression) of CYP3A5 associated with nicotine addiction
8) Confidence 0.40 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.91 Pain Relevance 0

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