INT121683

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 7.15
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hc) extracellular region (Hc)
Anatomy Link Frequency
aorta 2
cleavage 2
sperm 2
neuronal 1
endothelial cells 1
Hc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 20 100.00 Very High Very High Very High
Hippocampus 8 100.00 Very High Very High Very High
Arthritis 84 99.28 Very High Very High Very High
intrathecal 1 99.06 Very High Very High Very High
Hyperalgesia 4 98.48 Very High Very High Very High
rheumatoid arthritis 70 97.44 Very High Very High Very High
ischemia 20 92.88 High High
Opioid 1 92.68 High High
Inflammation 110 90.96 High High
opiate 1 90.04 High High
Disease Link Frequency Relevance Heat
Infection 110 99.44 Very High Very High Very High
Arthritis 88 99.28 Very High Very High Very High
Injury 52 98.60 Very High Very High Very High
Hyperalgesia 9 98.48 Very High Very High Very High
Targeted Disruption 31 98.24 Very High Very High Very High
Rheumatoid Arthritis 70 97.44 Very High Very High Very High
Genetic Predisposition To Disease 9 94.56 High High
Sprains And Strains 239 94.44 High High
Disease 78 94.28 High High
Coronary Artery Disease 7 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, challenge with cobra venom factor, which can activate and deplete almost all complement in vivo, induced a lethal effect on proCPR(-/-) mice following LPS sensitization which up-regulates C5a receptor expression.
Gene_expression (expression) of C5a
1) Confidence 0.75 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15383602 Disease Relevance 0.15 Pain Relevance 0.23
They also measured changes in C5a receptor expression near the incisions.
Gene_expression (expression) of C5a
2) Confidence 0.75 Published 2006 Journal Anesthesiology Section Body Doc Link 16732100 Disease Relevance 0.16 Pain Relevance 0
For H-E staining, the sections were stained with Mayer's hematoxylin, followed by eosin staining.
Gene_expression (staining) of H-E
3) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912385 Disease Relevance 0.06 Pain Relevance 0
A reduction > or = 90% of the initial ulcer area was seen in 15 patients in the HC + HA dressing group and in only seven patients in the HC dressing group.
Gene_expression (dressing) of HC
4) Confidence 0.58 Published 2008 Journal Curr Med Res Opin Section Body Doc Link 18713490 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: The HC + HA dressing was equally well tolerated and with a trend to be more effective than the reference HC dressing in the treatment of leg ulcers of venous or mixed origin.
Gene_expression (dressing) of HC in leg
5) Confidence 0.58 Published 2008 Journal Curr Med Res Opin Section Body Doc Link 18713490 Disease Relevance 0.05 Pain Relevance 0
The addition of W-54011, a specific C5a-receptor antagonist, significantly inhibited C5a-induced proliferation in a dose-dependent manner, whereas W-54011 alone had no effect (Fig. 2d).Fig. 1Expression of C5aR (CD88) on human microvascular endothelial cells (HMEC-1).
Gene_expression (1Expression) of C5a in endothelial cells associated with antagonist
6) Confidence 0.58 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0 Pain Relevance 0.07
Differences between mouse and human heart or the fact that TRPC4 and C5 are not constitutively expressed may be responsible for these findings.
Neg (not) Gene_expression (expressed) of C5 in heart
7) Confidence 0.24 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.06 Pain Relevance 0
Systemic C5 inhibition in clinical studies has resulted in mixed results and the role of earlier complement components (e.g., C3a), upstream from C5 cleavage, has not been elucidated for MI/R injury.
Gene_expression (cleavage) of C5 in cleavage associated with injury
8) Confidence 0.23 Published 2010 Journal GMS German Medical Science Section Abstract Doc Link PMC2940219 Disease Relevance 1.05 Pain Relevance 0.21
In addition, we observed the presence of TRPC2 in the aorta, but very low signals for TRPC4 and C5.
Gene_expression (presence) of C5 in aorta
9) Confidence 0.21 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.09 Pain Relevance 0.07
For TRPC3, C5 and TRPC6 positive reactions were observed in the cytoplasm of neuronal cells in the C2 area of the hippocampus without any strong variation of expression levels (Fig. 4A).
Gene_expression (expression) of C5 in neuronal associated with hippocampus
10) Confidence 0.21 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.15
The objective of the study was to determine the prevalence of DHC in HC positive decedents and report the range of concentrations detected in these cases in order to evaluate the potential role of DHC in the deaths and determine the usefulness of including this analyte in opioid testing protocols.
Gene_expression (decedents) of HC associated with opioid
11) Confidence 0.19 Published 2009 Journal Journal of forensic and legal medicine Section Abstract Doc Link 19134999 Disease Relevance 0 Pain Relevance 0.18
Signals of TRPC1, C3, C4, C5 and C6 have been reported in mouse and rat aorta, while TRPC2 and C7 transcripts were not observed [7].
Gene_expression (Signals) of C5 in aorta
12) Confidence 0.19 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.09 Pain Relevance 0.08
Similar observations were seen with SWR mice that, in spite of expressing the I-Aq susceptibility gene, are resistant to CIA because of a genetic deficiency in producing C5 [15].
Gene_expression (producing) of C5 associated with arthritis
13) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.12 Pain Relevance 0.47
Measurement of the activated proinflammatory complement products that are generated after C5 cleavage, namely C5a and C5b-9, showed significantly elevated levels in RA joints.
Gene_expression (cleavage) of C5 in cleavage associated with rheumatoid arthritis
14) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.41 Pain Relevance 0.46
All three additional C5-deficient mice were resistant to S. aureus infection (median survival >120 h, Figure 2D), suggesting that factors other than C5 deficiency were responsible for the susceptibility of A/J mice to S. aureus.


Gene_expression (deficiency) of C5 associated with infection
15) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.84 Pain Relevance 0
All three additional C5-deficient mice were resistant to S. aureus infection (median survival >120 h, Figure 2D), suggesting that factors other than C5 deficiency were responsible for the susceptibility of A/J mice to S. aureus.


Gene_expression (resistant) of C5 associated with infection
16) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.78 Pain Relevance 0
HC-056456 blocks evoked Ca2+and Na+ entry
Gene_expression (entry) of HC-056456
17) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2729922 Disease Relevance 0 Pain Relevance 0
In this and other respects, HC-056456 produces a pharmacological phenocopy of the CatSper-null sperm.
Gene_expression (produces) of HC-056456 in sperm
18) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2729922 Disease Relevance 0 Pain Relevance 0
In concept, it remains possible that CatSper channel heterogeneity explains residual HC-056456-resistant current.
Gene_expression (explains) of HC-056456
19) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2729922 Disease Relevance 0 Pain Relevance 0
HC-056456 reversibly removes waveform asymmetry
Gene_expression (removes) of HC-056456
20) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2729922 Disease Relevance 0 Pain Relevance 0

General Comments

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