INT12169

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Context Info
Confidence 0.48
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.44
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina3n) extracellular region (Serpina3n)
Serpina3n (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 2 67.68 Quite High
metalloproteinase 9 67.40 Quite High
Bile 1 56.28 Quite High
Kinase C 6 55.16 Quite High
dorsal root ganglion 117 50.00 Quite Low
Pain 27 28.88 Quite Low
Neuropathic pain 99 22.12 Low Low
Inflammation 15 8.88 Low Low
Eae 18 5.00 Very Low Very Low Very Low
allodynia 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 246 100.00 Very High Very High Very High
Toxicity 2 99.76 Very High Very High Very High
Nephrotoxicity 5 86.08 High High
Apoptosis 9 51.32 Quite High
Ganglion Cysts 123 50.00 Quite Low
Necrosis 1 40.16 Quite Low
Injury 39 33.76 Quite Low
Pain 42 28.88 Quite Low
Neuropathic Pain 150 22.12 Low Low
Adhesions 3 17.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These four groups were A: Genes preferentially expressed in adult SNI: SERPINA3N, SERPINB2, IL-6 and MMP3, B: Genes preferentially expressed in young SNI: CASPASE 3, TLR4, CLIC-1 and MMP16, C: Genes equally expressed in both adult and young SNI: CREM, MCP-1, MAOA, IPTKC and CSF1; and D: Genes specific to the young SNI group: P2RY14 and C3.
Gene_expression (expressed) of SERPINA3N associated with nervous system injury
1) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2799401 Disease Relevance 0.98 Pain Relevance 0.06
These four groups were A: Genes preferentially expressed in adult SNI: SERPINA3N, SERPINB2, IL-6 and MMP3, B: Genes preferentially expressed in young SNI: CASPASE 3, TLR4, CLIC-1 and MMP16, C: Genes equally expressed in both adult and young SNI: CREM, MCP-1, MAOA, IPTKC and CSF1; and D: Genes specific to the young SNI group: P2RY14 and C3.
Gene_expression (expressed) of SERPINA3N associated with nervous system injury
2) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2799401 Disease Relevance 1.06 Pain Relevance 0.06
These four groups were A: Genes preferentially expressed in adult SNI: SERPINA3N, SERPINB2, IL-6 and MMP3, B: Genes preferentially expressed in young SNI: CASPASE 3, TLR4, CLIC-1 and MMP16, C: Genes equally expressed in both adult and young SNI: CREM, MCP-1, MAOA, IPTKC and CSF1; and D: Genes specific to the young SNI group: P2RY14 and C3.
Gene_expression (expressed) of SERPINA3N associated with nervous system injury
3) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2799401 Disease Relevance 0.96 Pain Relevance 0.06
However, p-aminophenol toxicity in vivo is directed toward the S-2 and S-3 segments, which are rich in gamma-glutamyl transpeptidase.
Gene_expression (directed) of S-2 associated with toxicity
4) Confidence 0.08 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1631900 Disease Relevance 0.43 Pain Relevance 0.16

General Comments

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