INT121700

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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0.90

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peptidase activity (MMP1) signal transduction (IL12RB1) extracellular region (MMP1)
proteinaceous extracellular matrix (MMP1)
IL12RB1 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 19 100.00 Very High Very High Very High
Pain 1 69.96 Quite High
Arthritis 1 68.04 Quite High
Disease Link Frequency Relevance Heat
Arthritis 2 85.56 High High
Arthralgia 1 69.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The IL-1beta-mediated induction of MMP-1 mRNA expression was attenuated by 10 microg/ml HA (p=0.026) and that of MMP-3 mRNA was strongly down-regulated in the presence of 10 or 1000 microg/ml HA (p<0.001).
IL-1beta-mediated Positive_regulation (induction) of Gene_expression (expression) of MMP-1 mRNA associated with metalloproteinase
1) Confidence 0.06 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.22 Pain Relevance 0.90

General Comments

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