INT121703

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.14
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL1B, MMP1) aging (IL1B) cell-cell signaling (IL1B)
cytosol (IL1B) extracellular space (IL1B) signal transduction (IL1B)
IL1B (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 33 100.00 Very High Very High Very High
Arthritis 34 96.56 Very High Very High Very High
rheumatoid arthritis 92 95.48 Very High Very High Very High
Inflammation 60 82.88 Quite High
Pain 2 72.56 Quite High
agonist 1 50.00 Quite Low
anakinra 1 13.84 Low Low
cytokine 49 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 1 99.04 Very High Very High Very High
Arthritis 30 96.56 Very High Very High Very High
Rheumatoid Arthritis 92 95.48 Very High Very High Very High
INFLAMMATION 63 77.84 Quite High
Arthralgia 2 72.56 Quite High
Disease 22 50.92 Quite High
Necrosis 7 23.76 Low Low
Cancer 8 23.40 Low Low
Experimental Arthritis 13 5.00 Very Low Very Low Very Low
Syndrome 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of MMP-1 and MMP-3 mRNAs was induced by IL-1beta.
IL-1beta Positive_regulation (induced) of Gene_expression (Expression) of MMP-1 associated with metalloproteinase
1) Confidence 0.49 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.23 Pain Relevance 0.89
reduced expression of both constructs, which does not reflect the response of endogenous MMP-1 and MMP-13, whose expression is induced by IL-1?
IL-1 Positive_regulation (induced) of Gene_expression (expression) of MMP-1
2) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
At the same time, IL-1 induces the production of MMP-1 and MMP-3 and enhances bone resorption; this is compatible with recent evidence from arthritis models and human RA suggesting that the tissue-destruction capacities of IL-1?
IL-1 Positive_regulation (induces) of Gene_expression (production) of MMP-1 associated with rheumatoid arthritis, hypercalcemia and arthritis
3) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.91 Pain Relevance 0.38

General Comments

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