INT121705

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.20
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, MMP3) extracellular region (IL1B, MMP3) aging (IL1B)
protein complex (MMP3) cell-cell signaling (IL1B) cytosol (IL1B)
IL1B (Homo sapiens)
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 28 100.00 Very High Very High Very High
Arthritis 31 96.96 Very High Very High Very High
rheumatoid arthritis 88 95.88 Very High Very High Very High
Inflammation 52 83.68 Quite High
Pain 2 72.56 Quite High
anakinra 1 14.64 Low Low
cytokine 49 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 1 99.44 Very High Very High Very High
Arthritis 25 96.96 Very High Very High Very High
Rheumatoid Arthritis 88 95.88 Very High Very High Very High
INFLAMMATION 54 77.84 Quite High
Arthralgia 1 72.56 Quite High
Intervertebral Disk Degeneration 7 53.44 Quite High
Disease 23 50.92 Quite High
Necrosis 8 23.76 Low Low
Cancer 8 23.40 Low Low
Volume Depletion And Dehydration 1 14.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of MMP-1 and MMP-3 mRNAs was induced by IL-1beta.
IL-1beta Positive_regulation (induced) of Gene_expression (Expression) of MMP-3 associated with metalloproteinase
1) Confidence 0.49 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.23 Pain Relevance 0.89
Therefore, in vitro IL-1 causes an increase expression of MMP-3, an enzyme increased in the degenerate disc [6]
IL-1 Positive_regulation (causes) of Gene_expression (expression) of MMP-3
2) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.05 Pain Relevance 0.03
At the same time, IL-1 induces the production of MMP-1 and MMP-3 and enhances bone resorption; this is compatible with recent evidence from arthritis models and human RA suggesting that the tissue-destruction capacities of IL-1?
IL-1 Positive_regulation (induces) of Gene_expression (production) of MMP-3 associated with rheumatoid arthritis, hypercalcemia and arthritis
3) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.91 Pain Relevance 0.38

General Comments

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