INT121726

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.40
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ngf, Akt1) signal transduction (Ngf, Akt1) nucleoplasm (Akt1)
transport (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1)
Ngf (Rattus norvegicus)
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 14 99.90 Very High Very High Very High
IPN 4 94.32 High High
Inflammation 10 91.60 High High
nociceptor 2 87.08 High High
Hyperalgesia 10 82.20 Quite High
Stimulus evoked pain 2 79.40 Quite High
c fibre 2 79.12 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 4 94.32 High High
INFLAMMATION 4 91.60 High High
Hyperalgesia 10 82.20 Quite High
Hypersensitivity 2 79.40 Quite High
Pain 2 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin and NGF induce phosphorylation of the PI3K downstream target AKT (protein kinase B), which is blocked by the PI3K inhibitors LY294002 and wortmannin, indicative of the activation of PI3K by both agents.
NGF Positive_regulation (induce) of Phosphorylation (phosphorylation) of protein kinase B associated with qutenza
1) Confidence 0.37 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385613 Disease Relevance 0.70 Pain Relevance 1.18
Capsaicin and NGF induce phosphorylation of the PI3K downstream target AKT (protein kinase B), which is blocked by the PI3K inhibitors LY294002 and wortmannin, indicative of the activation of PI3K by both agents.
NGF Positive_regulation (induce) of Phosphorylation (phosphorylation) of AKT associated with qutenza
2) Confidence 0.27 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385613 Disease Relevance 0.70 Pain Relevance 1.17

General Comments

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