INT121727

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pik3cb, Ephb1) cytoplasm (Pik3cb, Ephb1) endosome (Ephb1)
cytosol (Pik3cb) cell adhesion (Pik3cb) plasma membrane (Ephb1)
Anatomy Link Frequency
primary sensory neurons 1
Pik3cb (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 7 100.00 Very High Very High Very High
Inflammation 5 100.00 Very High Very High Very High
Hyperalgesia 5 97.64 Very High Very High Very High
Stimulus evoked pain 1 86.40 High High
nociceptor 1 78.28 Quite High
IPN 2 71.32 Quite High
c fibre 1 51.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 98.36 Very High Very High Very High
Hyperalgesia 5 97.64 Very High Very High Very High
Pain 1 86.40 High High
Hypersensitivity 1 86.20 High High
Inflammatory Pain 2 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
Phosphatidylinositol 3-kinase Positive_regulation (activates) of ERK in primary sensory neurons associated with hyperalgesia, qutenza and inflammation
1) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Title Doc Link 15385613 Disease Relevance 0.60 Pain Relevance 1.06

General Comments

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