INT121730

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb, Trpv1) signal transduction (Pik3cb) cell adhesion (Pik3cb)
plasma membrane (Trpv1) nucleus (Pik3cb) lipid metabolic process (Trpv1)
Pik3cb (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 5 100.00 Very High Very High Very High
qutenza 7 92.92 High High
IPN 2 88.56 High High
c fibre 1 79.40 Quite High
Inflammation 5 75.00 Quite High
nociceptor 1 52.64 Quite High
Stimulus evoked pain 1 44.96 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 5 100.00 Very High Very High Very High
INFLAMMATION 2 75.00 Quite High
Inflammatory Pain 2 59.88 Quite High
Hypersensitivity 1 44.96 Quite Low
Pain 1 44.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, PI3K induces heat hyperalgesia, possibly by regulating TRPV1 activity, in an ERK-dependent manner.
PI3K Regulation (regulating) of TRPV1 associated with hyperalgesia
1) Confidence 0.58 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385613 Disease Relevance 0.54 Pain Relevance 1.09

General Comments

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