INT121740

Context Info Confidence 0.26 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0.20 Pain Relevance 3.36

cytosol (Camk4) nucleoplasm (Camk4) signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4) cytoplasm (Camk4)

Anatomy Link Frequency spinal cord 1 Camk4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dorsal horn neuron 18 99.92 c fibre 18 96.50 Spinal cord 3 95.90 qutenza 15 92.40 Glutamate receptor 3 88.56 Dorsal horn 3 81.28 intrathecal 6 77.84 central sensitization 12 75.00 Kinase C 3 75.00 allodynia 3 69.12

Disease Link Frequency Relevance Heat Neuropathic Pain 3 69.12 Pain 3 68.08 Hypersensitivity 3 66.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inhibition of calcium calmodulin-dependent kinase (CaMK) has no effect, but pERK is reduced by inhibition of the tyrosine kinase Src.

Negative_regulation (Inhibition) of calmodulin-dependent kinase

1) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0 Pain Relevance 0.96

The induction of cAMP response element binding protein phosphorylation (pCREB) in spinal cord slices in response to C-fiber stimulation is suppressed by preventing ERK activation with the MAP kinase kinase inhibitor 2-(2-diamino-3-methoxyphenyl-4H-1-benzopyran-4-one (PD98059) and by PKA, PKC, and CaMK inhibitors.

Negative_regulation (inhibitors) of CaMK in spinal cord associated with c fibre and spinal cord

2) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0.20 Pain Relevance 1.43

Inhibition of calcium calmodulin-dependent kinase (CaMK) has no effect, but pERK is reduced by inhibition of the tyrosine kinase Src.

Negative_regulation (Inhibition) of CaMK

3) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0 Pain Relevance 0.96

General Comments

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