INT121740

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.20
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Camk4) nucleoplasm (Camk4) signal transduction (Camk4)
nucleocytoplasmic transport (Camk4) nucleus (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
spinal cord 1
Camk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 18 99.92 Very High Very High Very High
c fibre 18 96.50 Very High Very High Very High
Spinal cord 3 95.90 Very High Very High Very High
qutenza 15 92.40 High High
Glutamate receptor 3 88.56 High High
Dorsal horn 3 81.28 Quite High
intrathecal 6 77.84 Quite High
central sensitization 12 75.00 Quite High
Kinase C 3 75.00 Quite High
allodynia 3 69.12 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 3 69.12 Quite High
Pain 3 68.08 Quite High
Hypersensitivity 3 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of calcium calmodulin-dependent kinase (CaMK) has no effect, but pERK is reduced by inhibition of the tyrosine kinase Src.
Negative_regulation (Inhibition) of calmodulin-dependent kinase
1) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0 Pain Relevance 0.96
The induction of cAMP response element binding protein phosphorylation (pCREB) in spinal cord slices in response to C-fiber stimulation is suppressed by preventing ERK activation with the MAP kinase kinase inhibitor 2-(2-diamino-3-methoxyphenyl-4H-1-benzopyran-4-one (PD98059) and by PKA, PKC, and CaMK inhibitors.
Negative_regulation (inhibitors) of CaMK in spinal cord associated with c fibre and spinal cord
2) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0.20 Pain Relevance 1.43
Inhibition of calcium calmodulin-dependent kinase (CaMK) has no effect, but pERK is reduced by inhibition of the tyrosine kinase Src.
Negative_regulation (Inhibition) of CaMK
3) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0 Pain Relevance 0.96

General Comments

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