INT121741

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.20
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaca, Creb1) mitochondrion (Prkaca, Creb1) nucleus (Prkaca, Creb1)
Golgi apparatus (Prkaca) DNA binding (Creb1) protein complex (Prkaca)
Anatomy Link Frequency
spinal cord 2
Prkaca (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 6 100.00 Very High Very High Very High
Spinal cord 1 100.00 Very High Very High Very High
Dorsal horn neuron 6 94.40 High High
qutenza 5 87.52 High High
Glutamate receptor 1 83.04 Quite High
Dorsal horn 1 79.20 Quite High
intrathecal 2 75.76 Quite High
central sensitization 4 75.00 Quite High
Kinase C 1 75.00 Quite High
allodynia 1 67.04 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 67.04 Quite High
Pain 1 66.00 Quite High
Hypersensitivity 1 64.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of cAMP response element binding protein phosphorylation (pCREB) in spinal cord slices in response to C-fiber stimulation is suppressed by preventing ERK activation with the MAP kinase kinase inhibitor 2-(2-diamino-3-methoxyphenyl-4H-1-benzopyran-4-one (PD98059) and by PKA, PKC, and CaMK inhibitors.
PKA Negative_regulation (suppressed) of Positive_regulation (induction) of pCREB in spinal cord associated with c fibre and spinal cord
1) Confidence 0.10 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0.20 Pain Relevance 1.49

General Comments

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