INT121744

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Src, Ephb1) plasma membrane (Src, Ephb1) endosome (Ephb1)
mitochondrion (Src) enzyme binding (Src) response to stress (Src)
Anatomy Link Frequency
dorsal horn 2
Src (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 6 100.00 Very High Very High Very High
Kinase C 1 99.88 Very High Very High Very High
qutenza 5 98.42 Very High Very High Very High
Dorsal horn neuron 6 97.52 Very High Very High Very High
central sensitization 4 96.24 Very High Very High Very High
Glutamate receptor 1 74.72 Quite High
Spinal cord 1 53.92 Quite High
Dorsal horn 1 35.32 Quite Low
intrathecal 2 33.60 Quite Low
allodynia 1 29.24 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 29.24 Quite Low
Pain 1 28.72 Quite Low
Hypersensitivity 1 27.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
Src Positive_regulation (contribute) of Positive_regulation (activation) of ERK in dorsal horn associated with c fibre, kinase c, qutenza, central sensitization and dorsal horn neuron
1) Confidence 0.35 Published 2004 Journal J. Neurosci. Section Title Doc Link 15385614 Disease Relevance 0 Pain Relevance 0.96

General Comments

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