INT121746

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Prkaca, Ephb1) plasma membrane (Prkaca, Ephb1) endosome (Ephb1)
nucleoplasm (Prkaca) mitochondrion (Prkaca) Golgi apparatus (Prkaca)
Anatomy Link Frequency
spinal cord 1
dorsal horn 1
Prkaca (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 1 99.78 Very High Very High Very High
long-term potentiation 4 99.72 Very High Very High Very High
Dorsal horn neuron 8 99.60 Very High Very High Very High
c fibre 6 99.56 Very High Very High Very High
central sensitization 11 98.44 Very High Very High Very High
Spinal cord 6 97.88 Very High Very High Very High
Pain 70 97.12 Very High Very High Very High
Neuronal excitability 1 94.72 High High
allodynia 1 92.16 High High
qutenza 5 90.60 High High
Disease Link Frequency Relevance Heat
Pain 70 97.12 Very High Very High Very High
Hypersensitivity 2 93.96 High High
Neuropathic Pain 3 92.16 High High
Arthritis 63 84.44 Quite High
Nociception 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is different from pain-related plasticity in the spinal cord [39,40] and from other models of plasticity such as hippocampal long-term potentiation (LTP) [61], where PKA and PKC act in concert to activate ERK.
PKA Positive_regulation (activate) of ERK in spinal cord associated with pain, long-term potentiation and spinal cord
1) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.64 Pain Relevance 1.01
We postulate that activation of ionotropic and metabotropic receptors by C-fiber nociceptor afferents activates ERK via both PKA and PKC, and that this contributes to central sensitization through post-translational and CREB-mediated transcriptional regulation in dorsal horn neurons.
PKA Positive_regulation (activates) of ERK in dorsal horn associated with c fibre, central sensitization, nociceptor and dorsal horn neuron
2) Confidence 0.18 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0.28 Pain Relevance 1.33

General Comments

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