INT121752

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 54
Total Number 56
Disease Relevance 18.05
Pain Relevance 7.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL11) extracellular region (IL11) cell-cell signaling (IL11)
cytoplasm (IL11)
Anatomy Link Frequency
decidua 9
epithelial cells 3
connective tissue 3
macrophages 2
fibroblasts 2
IL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 592 100.00 Very High Very High Very High
chemokine 113 100.00 Very High Very High Very High
Osteoarthritis 80 100.00 Very High Very High Very High
rheumatoid arthritis 383 99.92 Very High Very High Very High
metalloproteinase 128 98.16 Very High Very High Very High
Crohn's disease 1 97.00 Very High Very High Very High
Arthritis 196 96.80 Very High Very High Very High
medulla 1 95.96 Very High Very High Very High
Inflammation 473 94.44 High High
Infliximab 1 87.00 High High
Disease Link Frequency Relevance Heat
Metastasis 373 100.00 Very High Very High Very High
Knee Osteoarthritis 67 100.00 Very High Very High Very High
Leukemia 40 100.00 Very High Very High Very High
Reprotox - General 3 34 99.98 Very High Very High Very High
Rheumatoid Arthritis 395 99.92 Very High Very High Very High
Disease 187 99.68 Very High Very High Very High
Cancer 358 99.52 Very High Very High Very High
Respiratory Syncytial Virus 3 98.72 Very High Very High Very High
Breast Cancer 50 98.36 Very High Very High Very High
Hematological Disease 39 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, we have shown that both IL-11 and GP130 mRNA expression are elevated in the late secretory phase of the menstrual cycle whereas IL-11R?
Gene_expression (expression) of IL-11
1) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.06
Ablation of endogenous PROK1 in first trimester decidua inhibited IL-11 expression confirming that PROK1 regulates the basal expression and secretion of IL-11.
Gene_expression (expression) of IL-11 in decidua
2) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05
IL-11 is known to enhance progesterone mediated decidualization and that relaxin and PGE2 enhance IL-11 expression (Dimitriadis et al., 2002, 2005a, b).
Gene_expression (expression) of IL-11
3) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.12 Pain Relevance 0.08
As IL-11 expression is regulated via the calcineurin–NFAT signal transduction pathway, we investigated if the IL-11 promoter sequence contained any NFAT binding sites.
Gene_expression (expression) of IL-11
4) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
and PROKR1 in glandular epithelium and stroma suggesting the potential for PROK1–PROKR1 to regulate IL-11 expression in both compartments during endometrial receptivity and early pregnancy in an autocrine–paracrine manner.
Gene_expression (expression) of IL-11 in epithelium
5) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04
Therefore PROK1–PROKR1 could increase IL-11 expression and secretion directly during decidualization in a complementary manner.
Gene_expression (expression) of IL-11
6) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.13 Pain Relevance 0.08
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Gene_expression (expression) of IL-11
7) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
These data indicate that IL-11 expression in Ishikawa cells is regulated via PROK1-PROKR1 and downstream activation of the Gq–calcium–ERK–calcineurin–NFAT signal transduction pathway.


Gene_expression (expression) of IL-11
8) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
To investigate the signalling pathways mediating the role of PROK1 on IL-11 expression, PROKR1 Ishikawa cells were stimulated with vehicle or 40 nM PROK1 for 6 h in the presence or absence of the chemical inhibitors of Gq/11 (YM254890), a calcium chelator (EGTA), ERK (PD98059), NFAT (INCA-6) or calcineurin (CSA; cyclosporine A).
Gene_expression (expression) of IL-11
9) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.06 Pain Relevance 0
Since we have shown that PROK1 increases the expression and secretion of IL-11 we subsequently investigated whether PROK1 altered the expression levels of the receptors for IL-11—namely IL-11R?
Gene_expression (expression) of IL-11
10) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.06 Pain Relevance 0
Here, we have shown that RCAN1-4 is temporally regulated in a reciprocal manner to expression of IL-11 by PROK1–PROKR1.
Gene_expression (expression) of IL-11
11) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
In order to confirm the physiological relevance of our data, we investigated the effect of PROK1 on expression of IL-11 in first trimester decidua tissue explants.
Gene_expression (expression) of IL-11 in decidua
12) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.03
Since we have shown that PROK1 increases the expression and secretion of IL-11 we subsequently investigated whether PROK1 altered the expression levels of the receptors for IL-11—namely IL-11R?
Gene_expression (expression) of IL-11
13) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0
Moreover, using a specific inhibitor, INCA-6, which is known to block the interaction between calcineurin and NFAT (Roehrl et al., 2004), we have shown that inhibiting NFAT signalling can block PROK1-PROKR1 mediated expression of IL-11.
Gene_expression (expression) of IL-11
14) Confidence 0.62 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.06
PK analysis showed that most subjects (27/34, 79%) had undetectable serum levels of IL-11.
Gene_expression (levels) of IL-11
15) Confidence 0.60 Published 2004 Journal Biopharm Drug Dispos Section Abstract Doc Link 15386478 Disease Relevance 0.33 Pain Relevance 0.17
rhIL-11 has previously been assessed in a Phase-I/II, masked, placebo-controlled trial in patients with active Crohn's disease.
Gene_expression (assessed) of rhIL-11 associated with crohn's disease and disease
16) Confidence 0.59 Published 2001 Journal Arthritis Res Section Body Doc Link PMC34114 Disease Relevance 1.18 Pain Relevance 0.54
IL-11 signals initially by binding to its low affinity receptor IL-11R?
Gene_expression (signals) of IL-11
17) Confidence 0.53 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0.05
We subsequently investigated whether PROK1 can regulate expression of IL-11 in first trimester decidua tissue explants.
Gene_expression (expression) of IL-11 in decidua
18) Confidence 0.53 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
PROK1 induced expression of IL-11 mRNA at 24 h was significantly reduced by co-treatment of tissue explants with a Gq/11 inhibitor (P < 0.05), a calcium chelator (P < 0.01) or an ERK inhibitor (P < 0.01) (Fig. 5B).
Gene_expression (expression) of IL-11
19) Confidence 0.53 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
PROK1 induces the expression and secretion of IL-11 but not PROKR1 or GP130 in first trimester decidua via a Gq–Ca2+–ERK dependent pathway
Gene_expression (expression) of IL-11 in decidua
20) Confidence 0.53 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0

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