INT121759

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Context Info
Confidence 0.73
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.78
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Syp)
Anatomy Link Frequency
CeA 2
neurons 1
nerve 1
cortex 1
Syp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 9 99.90 Very High Very High Very High
amygdala 316 99.68 Very High Very High Very High
nMDA receptor 22 98.44 Very High Very High Very High
Neuropeptide 1 98.32 Very High Very High Very High
agonist 11 97.12 Very High Very High Very High
antagonist 20 96.52 Very High Very High Very High
long-term potentiation 59 96.00 Very High Very High Very High
Glutamate 9 94.78 High High
gABA 1 91.72 High High
Spinal cord 4 91.40 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 154 97.76 Very High Very High Very High
Targeted Disruption 52 97.68 Very High Very High Very High
Amyloid Plaque 10 83.28 Quite High
Death 8 82.72 Quite High
Alzheimer's Dementia 29 81.40 Quite High
Disease 20 78.08 Quite High
Neurodegenerative Disease 3 75.84 Quite High
Urological Neuroanatomy 7 75.00 Quite High
Pain 5 64.40 Quite High
Depression 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunoreactivity of mu opioid receptors was colocalized with synaptophysin, a presynaptic marker, in close appositions to labeled CeA neurons.
Localization (colocalized) of synaptophysin in CeA associated with mu opioid receptor and amygdala
1) Confidence 0.73 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15388784 Disease Relevance 0.25 Pain Relevance 0.79
Double immunofluorescence labeling showed that some of the immunoreactivities of Kv1.1 and Kv1.2 were colocalized with synaptophysin in the BLA.
Localization (colocalized) of synaptophysin in BLA associated with amygdala
2) Confidence 0.73 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16306173 Disease Relevance 0 Pain Relevance 0.85
Double immunofluorescent labeling showed that alpha-Syn colocalized with synaptophysin in the presynaptic nerve terminals, with neuropeptide Y (NPY) in lamina I, II, IX and X, and had close relationships with tyrosine hydroxylase (TH) immunoreactive neurons in laminae VII and X.
Localization (colocalized) of synaptophysin in nerve associated with neuropeptide
3) Confidence 0.73 Published 2009 Journal Neuroscience Section Abstract Doc Link 19118601 Disease Relevance 0.35 Pain Relevance 0.26
Another study employed dihydrexidine (D1/5 agonist) stimulation of cultured hippocampal neurons while NMDA receptors were blocked with APV, and found that the surface GluR1 immunoreactivity and colocalization with synaptophysin was reduced, and the mEPSC frequency was inhibited [27], thus exhibiting a cellular outcome for this ambiguous form of transactivation between these two types of receptors.
Localization (colocalization) of synaptophysin in neurons associated with nmda receptor and agonist
4) Confidence 0.73 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.22
While further studies are required, the co-localization of BACE1 immunoreactivity with synaptophysin, but not MAP2, suggested a presynaptic localization for BACE1.
Localization (localization) of synaptophysin
5) Confidence 0.73 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.82 Pain Relevance 0
In cultures of neurons from the visual cortex, however, both EP2 and EP3 are highly colocalized with PSD-95 (EP2, 71%; EP3, 82%), but less colocalized with synaptophysin (EP2, 25%; EP3, 13%) (Akaneya and Tsumoto, 2006).
Localization (colocalized) of synaptophysin in cortex
6) Confidence 0.73 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.15
For example, glutamate-induced LTP in hippocampal cell cultures has been shown to promote an increase in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin I and synaptophysin, as well as a corresponding increase in co-localization of GluR1 and synaptophysin/synapsin I-labeled puncta [24].
Localization (localization) of synaptophysin associated with glutamate and long-term potentiation
7) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0 Pain Relevance 0.19
Furthermore, colocalization with Synaptophysin demonstrated that 25% of axonal Eag1 was present in the membrane of presynaptic terminals (Fig. 1C and quantification in 4A).
Localization (colocalization) of Synaptophysin
8) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.08
In the present study, we show that auditory Pavlovian fear conditioning is associated with significant and persistent increases in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin and synaptophysin in the LA.
Localization (localized) of synaptophysin associated with anxiety disorder and amygdala
9) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.36 Pain Relevance 0.31

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