INT121763

Context Info Confidence 0.30 First Reported 2003 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.39 Pain Relevance 0

ribosome (Rps6ka1) nucleus (Rps6ka1) kinase activity (Rps6ka1) transcription factor binding (Rps6ka1) cytoplasm (Rps6ka1)

Anatomy Link Frequency cortex 1 Rps6ka1 (Mus musculus)

Pain Link Frequency Relevance Heat Action potential 1 49.68 tetrodotoxin 1 46.96 Bile 3 5.00 palliative 2 5.00 metalloproteinase 2 5.00 imagery 2 5.00 Chronic pancreatitis 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Death 14 98.88 Adenocarcinoma 60 96.80 Apoptosis 78 85.16 Cancer 169 82.96 Hepatocellular Cancer 72 50.00 Liver Cancer 24 35.36 Metastasis 9 28.08 Severe Combined Immunodeficiency 14 5.00 Cirrhosis 10 5.00 Disease 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, blocking p90Rsk activity by over-expression of a catalytically inactive form of p90Rsk enhanced Fas-mediated cell death [61].

Gene_expression (expression) of p90Rsk associated with death

1) Confidence 0.30 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.75 Pain Relevance 0

Furthermore, blocking p90Rsk activity by over-expression of a catalytically inactive form of p90Rsk enhanced Fas-mediated cell death [61].

Gene_expression (expression) of p90Rsk associated with death

2) Confidence 0.26 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.75 Pain Relevance 0

In this study, we ask: Are activated forms of ERK, RSK, and CREB colocalized in the cortex and are they coordinately regulated by synaptic signals?

Gene_expression (forms) of RSK in cortex

3) Confidence 0.22 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15389611 Disease Relevance 0 Pain Relevance 0

The four cytoplasmic proteins, S473p-PKB, p-S6K, p-S6 and p-NF?

Gene_expression (p-S6) of p-S6

4) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.88 Pain Relevance 0

General Comments

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