INT121765

Context Info Confidence 0.18 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.29 Pain Relevance 0

ribosome (Rps6ka1) nucleus (Rps6ka1) kinase activity (Rps6ka1) transcription factor binding (Rps6ka1) cytoplasm (Rps6ka1)

Anatomy Link Frequency cortex 1 Rps6ka1 (Mus musculus)

Pain Link Frequency Relevance Heat Action potential 1 49.68 tetrodotoxin 1 46.96 antagonist 7 18.24 palliative 1 5.00 anesthesia 1 5.00 Bile 1 5.00 metalloproteinase 1 5.00 isoflurane 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 54 92.56 Cancer 156 87.16 Death 10 84.48 Pressure And Volume Under Development 1 56.52 Malignant Neoplastic Disease 5 56.20 Metastasis 5 55.76 Disease 6 53.16 Hepatocellular Cancer 36 50.00 Pancreatic Cancer 21 50.00 Adenocarcinoma 11 45.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activated p90Rsk can phosphorylate Bad and prevent its proapoptotic activity [61].

Positive_regulation (Activated) of p90Rsk

1) Confidence 0.18 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.70 Pain Relevance 0

These effects are executed through a heterotrimeric G protein-coupled receptor, which mediates Ang II transactivated epidermal growth factor (EGF)-induced activation of MEK (MAPK kinase 1) and ERK [12].

Positive_regulation (activation) of MAPK kinase 1

2) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.59 Pain Relevance 0

In this study, we ask: Are activated forms of ERK, RSK, and CREB colocalized in the cortex and are they coordinately regulated by synaptic signals?

Positive_regulation (activated) of RSK in cortex

3) Confidence 0.15 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15389611 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.