INT121788

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 10.16
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCS1L) mitochondrion organization (BCS1L)
Anatomy Link Frequency
somas 2
placenta 2
BCS1L (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 7 99.48 Very High Very High Very High
abdominal pain 6 80.80 Quite High
opioid receptor 1 73.88 Quite High
cva 2 72.20 Quite High
member 8 16 71.76 Quite High
imagery 10 68.60 Quite High
Dynorphin 1 55.60 Quite High
Spinal cord 5 55.16 Quite High
Enkephalin 2 55.04 Quite High
Glutamate receptor 12 40.80 Quite Low
Disease Link Frequency Relevance Heat
Premature Birth 184 100.00 Very High Very High Very High
Budd-chiari Syndrome 76 100.00 Very High Very High Very High
Pre-term Labor 16 100.00 Very High Very High Very High
Dystonia Musculorum Deformans 5 100.00 Very High Very High Very High
Rupture 4 100.00 Very High Very High Very High
Thrombophilia 4 99.62 Very High Very High Very High
Diabetes Mellitus 4 98.72 Very High Very High Very High
Hypertension 2 98.16 Very High Very High Very High
Night Blindness 176 97.96 Very High Very High Very High
Congenital Anomalies 18 97.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that aberrant opioid transmission is unlikely to be present in DYT1-PTD and altered opioid transmission is not a common mechanism underlying all disorders of involuntary movement.
Localization (present) of PTD associated with dystonia musculorum deformans, opioid and dyskinesias
1) Confidence 0.73 Published 2004 Journal Mov. Disord. Section Abstract Doc Link 15390064 Disease Relevance 1.38 Pain Relevance 0.68
Myeloproliferative disorders (especially PV) were the cause of BCS in 6 patients, 7 patients had plasmatic coagulation abnormalities, 1 patient took oestrogen medication as a possible underlying hypercoagulable condition and in 6 patients the aetiology of BCS remained unclear.
Localization (aetiology) of BCS associated with budd-chiari syndrome, myeloproliferative disorder, congenital anomalies and myelodysplastic syndromes
2) Confidence 0.65 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2838758 Disease Relevance 1.38 Pain Relevance 0.16
To identify a hypercoagulable state as the underlying etiology of BCS each patient received a comprehensive hematological evaluation.
Localization (etiology) of BCS associated with budd-chiari syndrome and thrombophilia
3) Confidence 0.65 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2838758 Disease Relevance 1.06 Pain Relevance 0.06
Preterm delivery (PTD) is due to either spontaneous preterm labor (PTL) (40%–50%), spontaneous preterm premature rupture of membranes (PPROM) (25%–40%), or obstetrically indicated PTD (20%–25%) as a result of maternal, placental or fetal complications (preeclampsia, renal disease, diabetes mellitus with vasculopathy, placenta previa or abruptio, and fetal growth restriction).11
Localization (indicated) of PTD in placenta associated with diabetes mellitus, rupture, premature birth, renal disease, placenta previa, pre-term labor and pre-eclampsia
4) Confidence 0.54 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 2.57 Pain Relevance 0.04
Preterm delivery (PTD) is due to either spontaneous preterm labor (PTL) (40%–50%), spontaneous preterm premature rupture of membranes (PPROM) (25%–40%), or obstetrically indicated PTD (20%–25%) as a result of maternal, placental or fetal complications (preeclampsia, renal disease, diabetes mellitus with vasculopathy, placenta previa or abruptio, and fetal growth restriction).11
Localization (indicated) of PTD in placenta associated with diabetes mellitus, rupture, premature birth, renal disease, placenta previa, pre-term labor and pre-eclampsia
5) Confidence 0.54 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 2.46 Pain Relevance 0.03
It is likely that one of the three genes that is localized at the dendritic terminals of ON BCs and contributing the cell activity, TRPM1, GRM6, or NYX, would responsible for most patients with complete CSNB.
Localization (localized) of BCs associated with night blindness
6) Confidence 0.09 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.62 Pain Relevance 0
TRPM1 WT was localized at the soma (arrow) and dendritic tips (arrowheads) of the ON BCs (Figure 3B,C).
Localization (localized) of BCs in soma
7) Confidence 0.09 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
We found that trpm1-L localization is developmentally restricted to the dendritic tips of ON BCs in co-localization with mGluR6 [11,19].
Localization (localization) of BCs
8) Confidence 0.09 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.52 Pain Relevance 0.14
We quantified the number of electroporated ON BCs in which the WT TRPM1 protein was localized more in the dendritic tips than somas.
Localization (localized) of BCs in somas
9) Confidence 0.09 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
The expression of pERBB2 could help predict clinical response of ERBB2-positive BCs to trastuzumab or lapatinib [8,42,43]. pERBB2 status was evaluated by IHC on 22 ERBB2-amplified samples (Figure 5) and was detected in 17/22 (Additionnal file 1-Tables S8-S9A).
Localization (response) of BCs
10) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.17 Pain Relevance 0
For this purpose, we used the model based on Robin BCs described and validated above.
Localization (based) of BCs
11) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2652101 Disease Relevance 0 Pain Relevance 0.03

General Comments

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