INT121792

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 2.81
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTN) extracellular region (PTN) endoplasmic reticulum (PTN)
Anatomy Link Frequency
margin 2
stromal cell 2
neurons 2
internal 2
neuronal 1
PTN (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 498 97.64 Very High Very High Very High
Spinal cord 8 89.28 High High
midbrain 120 88.76 High High
Inflammatory response 1 78.96 Quite High
Inflammation 14 75.00 Quite High
Action potential 28 64.72 Quite High
Osteoarthritis 4 48.08 Quite Low
fibrosis 12 39.12 Quite Low
cINOD 1 38.88 Quite Low
gABA 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dermal Scarring 192 100.00 Very High Very High Very High
INFLAMMATION 15 78.96 Quite High
Targeted Disruption 31 75.00 Quite High
Hypersensitivity 1 75.00 Quite High
Disease 121 68.16 Quite High
Asthma 1 66.80 Quite High
Neurodegenerative Disease 43 65.52 Quite High
Peripheral Arterial Disease 16 56.52 Quite High
Shock 8 53.12 Quite High
Osteoarthritis 4 48.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the factors highly expressed by PA6 cells, and known to be associated with CNS development, were stromal cell-derived factor 1 (SDF-1/CXCL12), pleiotrophin (PTN), insulin-like growth factor 2 (IGF2), and ephrin B1 (EFNB1).
Gene_expression (expressed) of pleiotrophin in stromal cell
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.10
Analysis of PTNs
Gene_expression (Analysis) of PTN
2) Confidence 0.65 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0.05 Pain Relevance 0.03
PTNs were detected and clustered using modified Wave_clus software (Quiroga et al., 2004).
Gene_expression (detected) of PTN
3) Confidence 0.65 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0.05 Pain Relevance 0.03
The F5 PTNs we recorded were found in the same region of area F5 as in the original report by Gallese et al. (1996) and were mostly located on the convexity of the gyrus, as predicted from retrograde labeling of corticospinal neurons (He et al., 1993).
Gene_expression (found) of PTN in neurons
4) Confidence 0.58 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0 Pain Relevance 0.04
In a previous study we showed, using the whole genome microarray approach, that pleiotrophin (PTN) expression was increased by 4-fold in response to mechanical loading (ML) in a good responder C57BL/6J (B6) mice.
Gene_expression (expression) of pleiotrophin
5) Confidence 0.58 Published 2008 Journal BMC Res Notes Section Abstract Doc Link PMC2612677 Disease Relevance 0.07 Pain Relevance 0
The GAG heparin, co-released with histamine, is synthesised by and stored exclusively in mast cells, whereas the closely related molecule heparan sulphate is expressed, as part of a proteoglycan, on cell surfaces and throughout tissue matrices.
Gene_expression (synthesised) of heparin in mast cells
6) Confidence 0.52 Published 2004 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 15446270 Disease Relevance 0.60 Pain Relevance 0.17
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of PTN in internal associated with dermal scarring
7) Confidence 0.45 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
Among the factors highly expressed by PA6 cells, and known to be associated with CNS development, were stromal cell-derived factor 1 (SDF-1/CXCL12), pleiotrophin (PTN), insulin-like growth factor 2 (IGF2), and ephrin B1 (EFNB1).
Gene_expression (expressed) of PTN in stromal cell
8) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.10
Thus, the combination of the four factors SDF-1, PTN, IGF2, and EFNB-1 termed “SPIE”, can to some degree mimic SDIA and produce a high yield of TH+ neurons from hESC in the presence of heparin.
Gene_expression (termed) of PTN in neurons
9) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.28
In addition, PTN, Fibroblast growth factor-10 (FGF10), and serpin peptidase inhibitor, clade E (SERPINE2) also known as glial-derived neurite promoting factor, were classified as heparin binding factors by gene ontology in molecular function at level six.
Gene_expression (classified) of PTN in Fibroblast
10) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.06 Pain Relevance 0.15
As shown in Table 1, the selected genes SDF-1(CXCL12) and EFNB1 were included in the CNS and neuronal development category, while PTN was placed in the tissue development gene cluster by FatiGO.
Gene_expression (placed) of PTN in neuronal
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.07 Pain Relevance 0.15
The following final concentrations of the selected growth factors were used: SDF-1 (100 ng/ml), PTN (100 ng/ml), IGF2 (100 ng/ml), IGFBP4 (500 ng/ml), and EFNB1 (200 ng/ml); all from R&D Systems.
Gene_expression (used) of PTN
12) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of PTN in internal associated with dermal scarring
13) Confidence 0.20 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
Note also that during action observation, the PTN fired with maximum rates similar to those observed during the monkey's own grasping movement (Figure 2C).
Gene_expression (fired) of PTN
14) Confidence 0.18 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0.11 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of PTN in margin associated with dermal scarring
15) Confidence 0.15 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of PTN in margin associated with dermal scarring
16) Confidence 0.07 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0

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