INT121800

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 10.86
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pancreas 2
pancreatic duct 2
Arigg4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 70 99.80 Very High Very High Very High
Chronic pancreatitis 25 99.28 Very High Very High Very High
Inflammation 30 98.60 Very High Very High Very High
Bile 17 98.32 Very High Very High Very High
fibrosis 38 96.56 Very High Very High Very High
corticosteroid 79 86.96 High High
alcohol 2 84.48 Quite High
abdominal pain 25 83.40 Quite High
Inflammatory marker 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 99 99.96 Very High Very High Very High
Carcinoma 1 99.88 Very High Very High Very High
Pancreatitis 444 99.84 Very High Very High Very High
Pancreatic Cancer 7 99.20 Very High Very High Very High
INFLAMMATION 34 98.60 Very High Very High Very High
Biliary Liver Cirrhosis 3 98.40 Very High Very High Very High
Autoimmune Disease 6 98.04 Very High Very High Very High
Primary Sclerosing Cholangitis 3 97.32 Very High Very High Very High
Retroperitoneal Fibrosis 12 97.20 Very High Very High Very High
Cancer 11 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated serum IgG4 levels have been described in patients with LPSP and have been used to distinguish LPSP from pancreatic carcinoma preoperatively.
Positive_regulation (Elevated) of Gene_expression (levels) of IgG4 associated with pancreatic cancer and pancreatitis
1) Confidence 0.31 Published 2004 Journal Semin Diagn Pathol Section Abstract Doc Link 16273942 Disease Relevance 1.58 Pain Relevance 0.33
Elevated serum IgG4 levels are characteristic and may be very helpful in the differential diagnosis from tumors and tumor-like lesions of the pancreas which seldom result in levels above 135 mg/dL.
Positive_regulation (Elevated) of Gene_expression (levels) of IgG4 in pancreas associated with cancer
2) Confidence 0.02 Published 2005 Journal Semin Diagn Pathol Section Abstract Doc Link 16939059 Disease Relevance 1.29 Pain Relevance 0.25
In addition to elevated serum IgG4 levels, IgG4 immunostaining of involved tissue is often used to support the diagnosis of AIP.
Positive_regulation (elevated) of Gene_expression (levels) of IgG4 associated with pancreatitis
3) Confidence 0.02 Published 2010 Journal Dig Surg Section Abstract Doc Link 20551653 Disease Relevance 0.66 Pain Relevance 0.09
They did not find elevated serum IgG4 levels in patients with chronic pancreatitis, primary biliary cirrhosis, primary sclerosing cholangitis, nor Sjogren syndrome [6].
Neg (not) Positive_regulation (elevated) of Spec (find) Gene_expression (levels) of IgG4 associated with biliary liver cirrhosis, sjoegrens syndrome, primary sclerosing cholangitis and chronic pancreatitis
4) Confidence 0.02 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.46 Pain Relevance 0.32
Elevated IgG4 levels in AIP
Positive_regulation (Elevated) of Gene_expression (levels) of IgG4 associated with pancreatitis
5) Confidence 0.02 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.51 Pain Relevance 0.38
Elevated serum IgG4 levels and positive IgG4 immunostaining have been associated not only with AIP, but also with retroperitoneal fibrosis, sialoadenitis, mediastinal adenopathy (as in the patient reported herein), cholangitis, and tubulointerstitial nephritis [3,21,22,27] and is one criterion for diagnosis in the HISORt criteria [3,5].
Positive_regulation (Elevated) of Gene_expression (levels) of IgG4 associated with fibrosis, interstitial nephritis, cholangitis, retroperitoneal fibrosis and pancreatitis
6) Confidence 0.02 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.18 Pain Relevance 0.14
Also in autoimmune pancreatitis, there are increased levels of gammaglobulins and characteristically high titres of IgG4, which are a subtype of IgG.
Positive_regulation (increased) of Gene_expression (subtype) of IgG4 associated with pancreatitis
7) Confidence 0.00 Published 2005 Journal Dig Liver Dis Section Abstract Doc Link 15888288 Disease Relevance 1.41 Pain Relevance 0.16
Laboratory studies typically demonstrate elevated serum IgG4 levels and imaging studies reveal a diffusely or focally enlarged pancreas with associated diffuse or focal narrowing of the pancreatic duct.
Positive_regulation (elevated) of Gene_expression (levels) of IgG4 in pancreatic duct associated with imagery
8) Confidence 0.00 Published 2007 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 17533077 Disease Relevance 0.76 Pain Relevance 0.19
Serum IgG4 levels were elevated in seven of them.
Positive_regulation (elevated) of Gene_expression (levels) of IgG4
9) Confidence 0.00 Published 2004 Journal Am. J. Gastroenterol. Section Abstract Doc Link 15447769 Disease Relevance 1.00 Pain Relevance 0.16

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