INT121801

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 22
Disease Relevance 24.10
Pain Relevance 5.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Aip) cytosol (Aip) nucleolus (Aip)
plasma membrane (Aip) nucleus (Aip) cytoplasm (Aip)
Anatomy Link Frequency
pancreas 2
lymph nodes 1
B-cell 1
bowel 1
pancreatic ducts 1
Aip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 69 100.00 Very High Very High Very High
Inflammation 40 100.00 Very High Very High Very High
imagery 121 99.98 Very High Very High Very High
fibrosis 73 98.72 Very High Very High Very High
corticosteroid 132 96.24 Very High Very High Very High
abdominal pain 41 95.76 Very High Very High Very High
Bile 27 87.08 High High
Inflammatory marker 10 72.68 Quite High
Pain 10 30.20 Quite Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 846 100.00 Very High Very High Very High
Disease 183 100.00 Very High Very High Very High
INFLAMMATION 49 100.00 Very High Very High Very High
Pressure And Volume Under Development 16 100.00 Very High Very High Very High
Autoimmune Disease 11 99.52 Very High Very High Very High
Retroperitoneal Fibrosis 25 99.36 Very High Very High Very High
Diabetes Mellitus 6 99.36 Very High Very High Very High
Pancreatic Cancer 12 99.28 Very High Very High Very High
Sialadenitis 2 99.24 Very High Very High Very High
Adenocarcinoma 1 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recognition of AIP can avoid major surgery such as pancreatic resection.
AIP Binding (recognition) of associated with pancreatitis
1) Confidence 0.36 Published 2008 Journal J Chin Med Assoc Section Abstract Doc Link 18218555 Disease Relevance 1.17 Pain Relevance 0.30
OBJECTIVE: With an increase in autoimmune pancreatitis (AIP) being reported, the focal type of AIP, which shows localized narrowing of the main pancreatic duct and focal swelling of the pancreas, has recently been recognized.
AIP Binding (recognized) of in pancreas associated with pressure and volume under development and pancreatitis
2) Confidence 0.31 Published 2008 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 18158696 Disease Relevance 0.98 Pain Relevance 0.24
Although AIP is rarely associated with pancreatic stones, stones are formed in some relapsing AIP patients.
AIP Binding (associated) of associated with pancreatitis
3) Confidence 0.31 Published 2007 Journal J. Gastroenterol. Section Abstract Doc Link 17520225 Disease Relevance 2.04 Pain Relevance 0.12
However, only in the last decade autoimmune pancreatitis (AIP) has been recognized as a distinct entity with typical histopathological and immunological findings.
AIP Binding (recognized) of associated with pancreatitis
4) Confidence 0.31 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 17073676 Disease Relevance 0.96 Pain Relevance 0.14
AIP is frequently associated with other autoimmune diseases, such as Sjogren's syndrome, sclerosing extra-hepatic cholangitis and retroperitoneal fibrosis.
AIP Binding (associated) of associated with fibrosis, cholangitis, autoimmune disease, retroperitoneal fibrosis, syndrome and pancreatitis
5) Confidence 0.31 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 17073676 Disease Relevance 1.01 Pain Relevance 0.14
Autoimmune chronic pancreatitis (AIP) is increasingly being recognized as a worldwide entity.
AIP Binding (recognized) of associated with chronic pancreatitis
6) Confidence 0.31 Published 2007 Journal Pancreas Section Abstract Doc Link 17414049 Disease Relevance 0.66 Pain Relevance 0.58
Autoimmune chronic pancreatitis (AIP) is increasingly being recognized worldwidely, as knowledge of this entity builds up.
AIP Binding (recognized) of associated with chronic pancreatitis
7) Confidence 0.31 Published 2006 Journal World J. Gastroenterol. Section Abstract Doc Link 16688792 Disease Relevance 0.75 Pain Relevance 0.66
OBJECTIVES: Autoimmune pancreatitis (AIP) is increasingly recognized as a form of chronic pancreatitis.
AIP Binding (recognized) of associated with pancreatitis and chronic pancreatitis
8) Confidence 0.30 Published 2009 Journal Am. J. Gastroenterol. Section Abstract Doc Link 19532132 Disease Relevance 0.47 Pain Relevance 0.10
In conclusion, our data indicate that the six criteria we applied were able to recognize AIP in 76% of biopsy specimens using a cut-off level of four.
AIP Binding (recognize) of associated with pancreatitis
9) Confidence 0.30 Published 2009 Journal Virchows Arch. Section Abstract Doc Link 19238431 Disease Relevance 1.23 Pain Relevance 0.36
The R81X is a known functional mutation that codes for a truncated protein lacking the tetratricopeptide repeat (TPR) carboxy terminal domains, which are essential for AIP to bind to the aryl hydrocarbon receptor (AHR) and heat shock 90 (HSP90).12,27 Previous in vitro studies of the R81X mutation have shown that it blocks the interaction of wild type AIP and phosphodiesterase type 4A (PDE4A), potentially disrupting the cAMP cascade.28

AIP somatic status in the somatotropinoma, adrenocortical tumor and B-cell non-Hodgkin lymphoma

AIP Binding (interaction) of in B-cell associated with cancer, shock and hodgkin's disease
10) Confidence 0.29 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 0.69 Pain Relevance 0
The following extrapancreatic lesions may be associated with AIP: biliary lesions, sialadenitis, retroperitoneal fibrosis, enlarged celiac and hilar lymph nodes, chronic thyroiditis, and interstitial nephritis9–14 (Table 2).
AIP Binding (associated) of in lymph nodes associated with fibrosis, thyroiditis, retroperitoneal fibrosis, pancreatitis and sialadenitis
11) Confidence 0.27 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780630 Disease Relevance 1.71 Pain Relevance 0.09
Additionally, AIP can be associated with other autoimmune diseases such as Sjögren's syndrome, primary sclerosing cholangitis, chronic inflammatory bowel diseases, and retroperitoneal fibrosis.
AIP Binding (associated) of in bowel associated with fibrosis, autoimmune disease, inflammation, retroperitoneal fibrosis, syndrome, primary sclerosing cholangitis and pancreatitis
12) Confidence 0.18 Published 2006 Journal Chirurg Section Abstract Doc Link 16208510 Disease Relevance 1.99 Pain Relevance 0.35
Although nowadays widely accepted as a form of chronic pancreatitis, recent evidence suggests that AIP might not be confined to the pancreas but rather be an inflammatory pancreaticobiliary disease (autoimmune pancreatocholangitis, AIPC) with possible systemic involvement and association with other autoimmune disorders.
AIP Binding (association) of in pancreas associated with autoimmune disease, inflammation, pancreatitis, disease and chronic pancreatitis
13) Confidence 0.18 Published 2008 Journal Minerva Gastroenterol Dietol Section Abstract Doc Link 19047978 Disease Relevance 1.17 Pain Relevance 0.24
Early recognition of AIP can prevent pancreaticoduodenectomy in these patients and effective treatment with steroids can be introduced.
AIP Binding (recognition) of associated with pancreatitis
14) Confidence 0.13 Published 2006 Journal Swiss Med Wkly Section Abstract Doc Link 16983597 Disease Relevance 1.04 Pain Relevance 0.16
Autoimmune pancreatitis (AIP) is a recognized benign disease characterized by irregular narrowing of the pancreatic duct, swelling of parenchyma, lymphoplasmacytic infiltration and fibrosis, and a favorable response to corticosteroid treatment.
AIP Binding (recognized) of in parenchyma associated with fibrosis, pressure and volume under development, corticosteroid, pancreatitis and disease
15) Confidence 0.12 Published 2004 Journal Am. J. Gastroenterol. Section Abstract Doc Link 15447769 Disease Relevance 0.61 Pain Relevance 0.09
Autoimmune pancreatitis (AIP) is a newly recognized disease.
AIP Binding (recognized) of associated with pancreatitis and disease
16) Confidence 0.10 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 17414098 Disease Relevance 0.80 Pain Relevance 0.22
RESULTS: There was a dense lymphoplasmacytic infiltrate, especially within and around the pancreatic ducts, and fibrosis associated with AIP, while there was fibrosis accompanied by mild inflammatory infiltration in both CAP and COP.
AIP Binding (associated) of in pancreatic ducts
17) Confidence 0.07 Published 2005 Journal Pancreas Section Body Doc Link 15841047 Disease Relevance 0.18 Pain Relevance 0
Elevated serum IgG4 levels and positive IgG4 immunostaining have been associated not only with AIP, but also with retroperitoneal fibrosis, sialoadenitis, mediastinal adenopathy (as in the patient reported herein), cholangitis, and tubulointerstitial nephritis [3,21,22,27] and is one criterion for diagnosis in the HISORt criteria [3,5].
AIP Binding (associated) of associated with fibrosis, interstitial nephritis, cholangitis, retroperitoneal fibrosis and pancreatitis
18) Confidence 0.07 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.29 Pain Relevance 0.15
In addition to the imaging and histologic characteristics of AIP, a sensitive and specific serologic association with elevated IgG4 serum levels was first described by Hamano et al. [6].
AIP Binding (association) of associated with pancreatitis and imagery
19) Confidence 0.07 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.49 Pain Relevance 0.39
Diagnostic criteria for AIP
AIP Binding (criteria) of associated with pancreatitis
20) Confidence 0.07 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.26 Pain Relevance 0.18

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