INT121802

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.88
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEAF1) plasma membrane (HTR1A) nucleus (DEAF1)
DNA binding (DEAF1) signal transducer activity (HTR1A) cytoplasm (DEAF1)
DEAF1 (Homo sapiens)
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Raphe 2 99.84 Very High Very High Very High
agonist 2 95.76 Very High Very High Very High
depression 6 95.56 Very High Very High Very High
fluoxetine 4 94.48 High High
noradrenaline 2 93.00 High High
Serotonin 2 92.32 High High
antidepressant 10 91.56 High High
Disease Link Frequency Relevance Heat
Deafness 2 100.00 Very High Very High Very High
Depression 6 95.56 Very High Very High Very High
Suicidal Behaviour 2 94.96 High High
Repression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 5-HT1A receptor gene is repressed by NUDR/DEAF-1 in raphe cells at the C-, but not at the G-allele of the C(-1019)G polymorphism that is associated with major depression and suicide.
NUDR Negative_regulation (repressed) of 5-HT1A associated with deafness, suicidal behaviour, depression and raphe
1) Confidence 0.46 Published 2004 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 15447813 Disease Relevance 0.44 Pain Relevance 0.64
The 5-HT1A receptor gene is repressed by NUDR/DEAF-1 in raphe cells at the C-, but not at the G-allele of the C(-1019)G polymorphism that is associated with major depression and suicide.
DEAF-1 Negative_regulation (repressed) of 5-HT1A associated with deafness, suicidal behaviour, depression and raphe
2) Confidence 0.20 Published 2004 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 15447813 Disease Relevance 0.44 Pain Relevance 0.65

General Comments

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