INT121810

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CAV2) mitochondrion organization (CAV2) intracellular (CAV2)
protein complex (CAV2) cytoplasm (CAV2) cytosol (CAV2)
Anatomy Link Frequency
brain 1
heart 1
CAV2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 1 99.64 Very High Very High Very High
antagonist 4 97.60 Very High Very High Very High
Migraine 2 90.76 High High
agonist 5 75.00 Quite High
Potency 1 62.72 Quite High
addiction 1 59.12 Quite High
Calcium channel 1 44.44 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 99.64 Very High Very High Very High
Myocardial Infarction 1 99.22 Very High Very High Very High
Disease 2 98.76 Very High Very High Very High
Migraine With Aura 2 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different beta-subunit isoforms (primarily beta4 and beta3) participate in the formation of Cav2.1 channel complexes in mammalian brain.
Positive_regulation (formation) of Cav2 in brain
1) Confidence 0.28 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15448138 Disease Relevance 0.25 Pain Relevance 0.20
Trisubstituted purine antagonists could become clinically important drugs to treat diseases, such as heart failure and neuropathic pain that result from elevated CaV2 channel activity.
Positive_regulation (elevated) of CaV2 in heart associated with antagonist, neuropathic pain, disease and myocardial infarction
2) Confidence 0.06 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18221369 Disease Relevance 0.30 Pain Relevance 0.37

General Comments

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