INT121814

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.83
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 14 99.50 Very High Very High Very High
analgesia 2 81.96 Quite High
Inflammation 17 81.24 Quite High
Endogenous opioid 2 75.24 Quite High
IPN 2 67.84 Quite High
rheumatoid arthritis 56 54.12 Quite High
cytokine 12 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 9 99.12 Very High Very High Very High
Neuroblastoma 2 86.76 High High
INFLAMMATION 15 81.24 Quite High
Repression 3 75.08 Quite High
Inflammatory Pain 2 67.84 Quite High
Apoptosis 24 57.52 Quite High
Rheumatoid Arthritis 56 54.12 Quite High
Death 6 48.40 Quite Low
Autoimmune Disease 6 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using transcription factor decoy oligonucleotides, direct evidence was provided that the up-regulation of mu-opioid receptor mRNA in intact cells is dependent on the transcription factors signal transducers and activators of transcription 1 (STAT1) and STAT3, whereas other transcription factors, such as activator protein-1, nuclear factor (NF)-kappaB, or NF-interleukin-6 are not involved.
Regulation (dependent) of STAT1 associated with opioid receptor
1) Confidence 0.43 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.24 Pain Relevance 0.56
Using transcription factor decoy oligonucleotides, direct evidence was provided that the up-regulation of mu-opioid receptor mRNA in intact cells is dependent on the transcription factors signal transducers and activators of transcription 1 (STAT1) and STAT3, whereas other transcription factors, such as activator protein-1, nuclear factor (NF)-kappaB, or NF-interleukin-6 are not involved.
Regulation (dependent) of signal transducers and activators of transcription 1 associated with opioid receptor
2) Confidence 0.43 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.24 Pain Relevance 0.56
As many genes such as IRAK1, IRAK2, TRAF6, FADD, IRF-5, STAT-1 and PTC1 have been found to be targets of miR-146a in human disease [20,31,34,46], the targets and functions of miR-146a may be different in specific cells.
Regulation (targets) of STAT-1 associated with disease
3) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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