INT121814

Context Info Confidence 0.43 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.83 Pain Relevance 1.15

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1) nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)

STAT1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 14 99.50 analgesia 2 81.96 Inflammation 17 81.24 Endogenous opioid 2 75.24 IPN 2 67.84 rheumatoid arthritis 56 54.12 cytokine 12 5.00 psoriasis 2 5.00 corticosteroid 1 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Disease 9 99.12 Neuroblastoma 2 86.76 INFLAMMATION 15 81.24 Repression 3 75.08 Inflammatory Pain 2 67.84 Apoptosis 24 57.52 Rheumatoid Arthritis 56 54.12 Death 6 48.40 Autoimmune Disease 6 5.00 Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using transcription factor decoy oligonucleotides, direct evidence was provided that the up-regulation of mu-opioid receptor mRNA in intact cells is dependent on the transcription factors signal transducers and activators of transcription 1 (STAT1) and STAT3, whereas other transcription factors, such as activator protein-1, nuclear factor (NF)-kappaB, or NF-interleukin-6 are not involved.

Regulation (dependent) of STAT1 associated with opioid receptor

1) Confidence 0.43 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.24 Pain Relevance 0.56

Using transcription factor decoy oligonucleotides, direct evidence was provided that the up-regulation of mu-opioid receptor mRNA in intact cells is dependent on the transcription factors signal transducers and activators of transcription 1 (STAT1) and STAT3, whereas other transcription factors, such as activator protein-1, nuclear factor (NF)-kappaB, or NF-interleukin-6 are not involved.

Regulation (dependent) of signal transducers and activators of transcription 1 associated with opioid receptor

2) Confidence 0.43 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.24 Pain Relevance 0.56

As many genes such as IRAK1, IRAK2, TRAF6, FADD, IRF-5, STAT-1 and PTC1 have been found to be targets of miR-146a in human disease [20,31,34,46], the targets and functions of miR-146a may be different in specific cells.

Regulation (targets) of STAT-1 associated with disease

3) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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