INT121815

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.75
Pain Relevance 7.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 191 100.00 Very High Very High Very High
agonist 68 100.00 Very High Very High Very High
Morphine 53 100.00 Very High Very High Very High
opiate 22 100.00 Very High Very High Very High
potassium channel 10 99.86 Very High Very High Very High
narcan 12 99.84 Very High Very High Very High
analgesia 26 98.36 Very High Very High Very High
Clonidine 38 97.44 Very High Very High Very High
Kinase C 6 96.40 Very High Very High Very High
antagonist 66 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 11 98.40 Very High Very High Very High
Mydriatic 13 93.64 High High
Opiate Addiction 2 93.52 High High
Neuroblastoma 6 89.16 High High
INFLAMMATION 1 83.64 Quite High
Inflammatory Pain 1 70.24 Quite High
Sleep Disorders 15 67.12 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

15 45.92 Quite Low
Anaplastic Astrocytoma 1 12.96 Low Low
Hypoxia 1 6.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of MOR1K activation on cAMP, Ca2+ and NO levels
Regulation (Effect) of Positive_regulation (activation) of MOR1K
1) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0 Pain Relevance 0.56
Expression of a dominant negative mutant G protein-coupled receptor kinase 2 (GRK2), GRK2-K220R, markedly attenuated the DAMGO-induced desensitization of MOR1, but it had no effect on morphine-induced MOR1 desensitization.
Neg (no) Regulation (effect) of Positive_regulation (morphine-induced) of MOR1 associated with morphine
2) Confidence 0.45 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 1.50
Using transcription factor decoy oligonucleotides, direct evidence was provided that the up-regulation of mu-opioid receptor mRNA in intact cells is dependent on the transcription factors signal transducers and activators of transcription 1 (STAT1) and STAT3, whereas other transcription factors, such as activator protein-1, nuclear factor (NF)-kappaB, or NF-interleukin-6 are not involved.
Regulation (dependent) of Positive_regulation (up-regulation) of mu-opioid receptor mRNA associated with opioid receptor
3) Confidence 0.29 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.24 Pain Relevance 0.57
Naloxone had no effect on the increase of MOP or ppdyn mRNA levels.
Neg (no) Regulation (effect) of Positive_regulation (increase) of MOP associated with narcan and opioid receptor
4) Confidence 0.25 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950784 Disease Relevance 0.17 Pain Relevance 0.54
These findings indicate that an allosteric modulation of mGluR5 can affect the agonist-induced MOR signalling and regulation.
Regulation (affect) of Positive_regulation (induced) of MOR associated with agonist and opioid receptor
5) Confidence 0.22 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 1.02
-opiate receptor mediated mechanisms is the usefulness of the ?
Regulation (usefulness) of Positive_regulation (mediated) of opiate receptor associated with opiate
6) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0.33 Pain Relevance 2.19
As glibenclamide reverted the analgesia induced by hydrogen sulphide, we hypothize that the ATP potassium channels could modulate MOR activation induced by hydrogen sulphide.
Regulation (modulate) of Positive_regulation (activation) of MOR associated with opioid receptor, potassium channel and analgesia
7) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.98

General Comments

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