INT121817

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 7 88.72 High High
analgesia 1 56.68 Quite High
Inflammation 2 55.96 Quite High
Endogenous opioid 1 49.96 Quite Low
IPN 1 42.56 Quite Low
fibrosis 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 32 97.20 Very High Very High Very High
Targeted Disruption 2 91.16 High High
Neuroblastoma 1 61.48 Quite High
INFLAMMATION 1 55.96 Quite High
Chronic Hepatitis C 1 50.00 Quite Low
Inflammatory Pain 1 42.56 Quite Low
Chronic Hepatitis 4 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Recurrence 3 5.00 Very Low Very Low Very Low
Liver Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A mutation analysis of the 5'-TTCATGGAA-3' STAT1/3 element (palindrome underlined) was performed to determine nucleotide residues that are necessary for the binding of STAT1 and STAT3.
Positive_regulation (necessary) of STAT1 Binding (binding) of
1) Confidence 0.67 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.12 Pain Relevance 0.30
induced transcription factor STAT1 and its binding to DNA response elements, thereby increasing the induction of ISGs and enhancing the inhibitory effect of IFN?
Positive_regulation (induced) of STAT1 Binding (binding) of
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975710 Disease Relevance 0.37 Pain Relevance 0

General Comments

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