INT121820

Context Info Confidence 0.46 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 10 Disease Relevance 2.54 Pain Relevance 1.40

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1) nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)

Anatomy Link Frequency nucleus 1 STAT1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 21 97.16 adenocard 2 92.92 agonist 113 89.20 cytokine 126 86.52 analgesia 3 72.24 Inflammation 192 71.52 metalloproteinase 13 66.28 Endogenous opioid 3 65.52 IPN 4 58.12 Potency 3 28.16

Disease Link Frequency Relevance Heat Hepatitis C Virus Infection 52 96.04 Apoptosis 42 91.96 Diabetes Mellitus 116 91.44 Targeted Disruption 6 90.00 Atherosclerosis 46 88.80 Leiomyosarcoma 59 80.56 Neuroblastoma 3 77.04 Cancer 57 75.68 Necrosis 13 75.60 INFLAMMATION 231 71.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Neither mutation of the nucleotides outside the palindrome nor mutation of the central nucleotide affected STAT1/3 binding.

STAT1 Binding (binding) of

1) Confidence 0.46 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.05 Pain Relevance 0.16

STAT1 and STAT3 bound to a site located at nucleotide -1583 on the promoter of the human mu-opioid receptor gene, as shown by transient transfection experiments, electrophoretic mobility shift assays, and transcription factor decoy oligonucleotides.

STAT1 Binding (bound) of associated with opioid receptor

2) Confidence 0.46 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.21 Pain Relevance 0.51

A mutation analysis of the 5'-TTCATGGAA-3' STAT1/3 element (palindrome underlined) was performed to determine nucleotide residues that are necessary for the binding of STAT1 and STAT3.

STAT1 Binding (binding) of

3) Confidence 0.46 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15448191 Disease Relevance 0.12 Pain Relevance 0.30

ST2L mRNA was weakly detected in unstimulated cells, and IL4 and interferon gamma (IFNgamma) strongly enhanced ST2L expression via STAT6 and STAT1 signalling, respectively.

STAT1 Binding (signalling) of

4) Confidence 0.30 Published 2010 Journal Gut Section Body Doc Link 19996325 Disease Relevance 0.05 Pain Relevance 0

The phosphorylated STAT1 forms homodimers that translocate to the nucleus and bind GAS (IFN-?

STAT1 Binding (bind) of in nucleus

5) Confidence 0.24 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.58 Pain Relevance 0

induced transcription factor STAT1 and its binding to DNA response elements, thereby increasing the induction of ISGs and enhancing the inhibitory effect of IFN?

STAT1 Binding (binding) of

6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975710 Disease Relevance 0.37 Pain Relevance 0

In the indirect mechanism, STAT1 is tyrosine-phosphorylated and dimerized after antocrine/paracrine interactions within IFN-?

STAT1 Binding (interactions) of

7) Confidence 0.11 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.13 Pain Relevance 0.14

In the indirect mechanism, STAT1 is tyrosine-phosphorylated and dimerized after antocrine/paracrine interactions within IFN-?

STAT1 Binding (dimerized) of

8) Confidence 0.11 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.12 Pain Relevance 0.11

In one study, Genistein, a nonspecific Tyr-kinase inhibitor, and AG490, a specific inhibitor of JAKs, markedly prevented the CuLDL-induced enhancement of STAT1 and STAT3 Tyr-phosphorylation and DNA-binding activity, suggesting that JAKs are the main kinases involved in STATs' activation by oxidized LDL [125].

STAT1 Binding (binding) of

9) Confidence 0.10 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.52 Pain Relevance 0.04

Couto et al[11] have recognized Janus kinase1-Signal transducer and activator of transcription1 (JAK1-STAT1) pathway as novel target of EX-4, where the drug produces downregulation of JAK1-STAT1 transduction mechanism which is an important signaling route mediating the interferon-gamma effects on beta-cell apoptosis in T1DM.

JAK1-STAT1 Binding (recognized) of associated with diabetes mellitus and apoptosis

10) Confidence 0.03 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.39 Pain Relevance 0.13

General Comments

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