INT121827

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.08
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 3
PGE2 3
endothelial cells 1
neurons 1
small intestine 1
Ccl21a (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 58 100.00 Very High Very High Very High
ischemia 62 98.76 Very High Very High Very High
Paracetamol 1 91.16 High High
Inflammatory mediators 2 91.04 High High
Analgesic 1 90.24 High High
Pain 3 83.36 Quite High
Hippocampus 2 80.72 Quite High
Inflammation 87 78.20 Quite High
medulla 41 78.16 Quite High
Arthritis 9 72.84 Quite High
Disease Link Frequency Relevance Heat
Thrombophilia 1 98.84 Very High Very High Very High
Cv Unclassified Under Development 50 98.76 Very High Very High Very High
Sprains And Strains 245 95.20 Very High Very High Very High
INFLAMMATION 104 91.04 High High
Infection 156 88.48 High High
Cancer 65 86.40 High High
Necrosis 2 85.92 High High
Death 21 85.84 High High
Rheumatoid Arthritis 96 85.20 High High
Vomiting 1 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, research studies designed to examine SLC gene expression and function (e.g., ability to transport sulfate and/or Cr(VI)) may be important to characterize interspecies difference in Cr(VI) uptake into the small intestine epithelial mucosa and to determine target tissue dose for pharmacokinetic and pharmacodynamic models.
Spec (examine) Gene_expression (expression) of SLC in small intestine
1) Confidence 0.75 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 0.07 Pain Relevance 0
Expression of MCP-1 and SLC is increased in neurons after ischemia [29,30].
Gene_expression (Expression) of SLC in neurons associated with ischemia
2) Confidence 0.75 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.98 Pain Relevance 0.46
The individual syntheses of PGE2 and pLT were quantified using competitive enzyme-immuno-assays followed by calculation of individual eicosanoid patterns.
Gene_expression (syntheses) of pLT in PGE2
3) Confidence 0.57 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15448594 Disease Relevance 0 Pain Relevance 0
RESULTS: Controls synthesized approximately 4.9-fold whereas patients only approximately 2.9-fold more PGE2 than pLT due to higher basal synthesis of pLT (67 and 125 pg/ml, respectively).
Gene_expression (synthesis) of pLT in PGE2
4) Confidence 0.49 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15448594 Disease Relevance 0 Pain Relevance 0
RESULTS: Controls synthesized approximately 4.9-fold whereas patients only approximately 2.9-fold more PGE2 than pLT due to higher basal synthesis of pLT (67 and 125 pg/ml, respectively).
Gene_expression (synthesized) of pLT in PGE2
5) Confidence 0.49 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15448594 Disease Relevance 0 Pain Relevance 0
The aphaeresis procedure itself causes an additional and more substantial PLT depletion and transient G-CSF-induced hypercoagulability in PBSC donors (Falanga et al., 1999; Topcuoglu et al., 2004).
Gene_expression (depletion) of PLT associated with thrombophilia
6) Confidence 0.10 Published 2010 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2871169 Disease Relevance 0.57 Pain Relevance 0.26
Homeostatic chemokines were detected with goat anti mouse CXCL13 and goat anti mouse CCL21.
Gene_expression (detected) of CCL21 associated with chemokine
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0 Pain Relevance 0.09
CCL21 was also detected in cells with an oval morphology compatible with endothelial cells or lymphatic precursors (lower right panel, figure 8A).
Gene_expression (detected) of CCL21 in endothelial cells
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.08 Pain Relevance 0.07
CCL21 was also detected by ELISA in lung lysates and serum from mice euthanized at day 30 post-challenge.
Gene_expression (detected) of CCL21 in lung
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.63 Pain Relevance 0.08
Levels of the CCL21 chemokine were measured in both serum and lung lysates of vaccinated/challenged mice by ELISA using the DuoSet Development System kit specific for CCL21/6Ckine (R&D Systems, Minneapolis, MN).


Gene_expression (Levels) of CCL21 in lung associated with chemokine
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.19 Pain Relevance 0.13
By ELISA assay, the levels of CCL21 in lung lysates and serum were elevated above baseline in the group vaccinated with LPS+rPorB and then challenged with LVS, as compared with unvaccinated unchallenged mice.
Gene_expression (levels) of CCL21 in lung associated with sprains and strains
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.10 Pain Relevance 0.07
Mature myeloid DC in perivascular, T-cell-enriched areas of synovial tissue are further characterized by expression of CD86, DC-LAMP and CCR7, and are associated with, and presumably attracted by, cells expressing the chemokines CCL19 (SLC) and CCL21 (ELC) [11,16,94].
Gene_expression (expressing) of CCL21 in T-cell associated with chemokine
12) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.47 Pain Relevance 0.18

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