INT121834

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Context Info
Confidence 0.66
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 20.96
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IAPP) extracellular region (IAPP) cell-cell signaling (IAPP)
Anatomy Link Frequency
beta cell 4
bladder 2
heart 2
pancreas 1
IAPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 119 95.16 Very High Very High Very High
nociceptor 5 69.44 Quite High
analgesia 4 50.00 Quite Low
headache 4 43.92 Quite Low
Nucleus accumbens 6 42.72 Quite Low
abdominal pain 4 27.92 Quite Low
antagonist 4 24.48 Low Low
fibrosis 4 11.28 Low Low
Pain 34 5.00 Very Low Very Low Very Low
metalloproteinase 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 731 100.00 Very High Very High Very High
Apoptosis 295 100.00 Very High Very High Very High
Alzheimer's Dementia 32 100.00 Very High Very High Very High
Targeted Disruption 22 99.88 Very High Very High Very High
Prediabetic State 78 99.66 Very High Very High Very High
Cancer 86 99.40 Very High Very High Very High
Insulin Resistance 126 99.28 Very High Very High Very High
Toxicity 83 98.92 Very High Very High Very High
Renal Insufficiency 2 96.88 Very High Very High Very High
INFLAMMATION 133 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite these potential adverse clinical consequences, however, IAP is commonly measured only when there is some clinical suspicion; furthermore, there is currently no general consensus on how frequently it should be measured [34].
Gene_expression (measured) of IAP
1) Confidence 0.66 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.15 Pain Relevance 0
However, this is not relevant in current clinical practice, because the IAP is usually measured with volumes of saline lower than 150 ml.
Gene_expression (measured) of IAP
2) Confidence 0.66 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.41 Pain Relevance 0.07
The following data were recorded: (i) patient characteristics, state of health or disease, medications and premedications; (ii) heart rate (HR), systolic arterial pressure (SAP), and diastolic arterial pressure (DAP) at 0600 hrs before surgery (baseline), on admission to the operating room, maximum and minimum values of HR, SAP and DAP recorded at the start of, and during, surgery; and (iii) all instances of benzodiazepine, opioid or NSAID drug administration during surgery, according to standard protocols.
Gene_expression (values) of DAP in heart
3) Confidence 0.65 Published 2004 Journal Middle East J Anesthesiol Section Body Doc Link 15449745 Disease Relevance 0 Pain Relevance 0
The following data were recorded: (i) patient characteristics, state of health or disease, medications and premedications; (ii) heart rate (HR), systolic arterial pressure (SAP), and diastolic arterial pressure (DAP) at 0600 hrs before surgery (baseline), on admission to the operating room, maximum and minimum values of HR, SAP and DAP recorded at the start of, and during, surgery; and (iii) all instances of benzodiazepine, opioid or NSAID drug administration during surgery, according to standard protocols.
Gene_expression (recorded) of DAP in heart
4) Confidence 0.65 Published 2004 Journal Middle East J Anesthesiol Section Body Doc Link 15449745 Disease Relevance 0 Pain Relevance 0
Iberti and colleagues [10], in a canine model of increased IAP, estimated bladder pressure with the bladder empty; they demonstrated that the IBP accurately reflected the IAP.
Gene_expression (reflected) of IAP in bladder
5) Confidence 0.58 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.39 Pain Relevance 0
Fusco and coworkers [22], using a human model in which IAP ranged between 0 and 25 mmHg during laparoscopic surgery, found that the bladder emptied (with a volume of 0 ml) yielded the most accurate estimation of IAP.
Gene_expression (ranged) of IAP in bladder
6) Confidence 0.58 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.38 Pain Relevance 0
Although these findings clearly indicate that the IBP can overestimate IAP when large volumes of saline are infused, the possible mechanisms involved are still not clearly understood.
Gene_expression (overestimate) of IAP
7) Confidence 0.58 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.45 Pain Relevance 0
Those authors measured IAP in 17 postoperative patients using the technique described above under Materials and methods.
Gene_expression (measured) of IAP
8) Confidence 0.57 Published 1999 Journal Crit Care Section Body Doc Link PMC29028 Disease Relevance 0.88 Pain Relevance 0
Ten patients had IAP of 10?
Gene_expression (had) of IAP
9) Confidence 0.57 Published 1999 Journal Crit Care Section Body Doc Link PMC29028 Disease Relevance 0.87 Pain Relevance 0
In type 2 diabetes, tissues become insulin resistant, the ability of the pancreatic ?
Gene_expression (resistant) of diabetes associated with diabetes mellitus
10) Confidence 0.40 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.82 Pain Relevance 0
Progressive therapeutic management of type 2 diabetes
Gene_expression (Progressive) of diabetes associated with diabetes mellitus
11) Confidence 0.40 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.99 Pain Relevance 0
Amylin may be considered to be the fraternal twin of insulin and has recently been shown to be a physiologic regulator of bone remodeling through favoring bone formation, while inhibiting bone resorption and thus is osteogenic [23] (table 3).


Gene_expression (twin) of Amylin associated with hypercalcemia
12) Confidence 0.32 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 2.63 Pain Relevance 0
In addition to insulin and IGF-1, there is another beta cell derived islet hormone that is elevated in IR, metS, prediabetes, and early T2DM termed amylin or islet amyloid polypeptide.
Gene_expression (termed) of islet amyloid polypeptide in beta cell associated with diabetes mellitus, alzheimer's dementia, prediabetic state and insulin resistance
13) Confidence 0.32 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 2.62 Pain Relevance 0
In addition to insulin and IGF-1, there is another beta cell derived islet hormone that is elevated in IR, metS, prediabetes, and early T2DM termed amylin or islet amyloid polypeptide.
Gene_expression (termed) of amylin in beta cell associated with diabetes mellitus, alzheimer's dementia, prediabetic state and insulin resistance
14) Confidence 0.32 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 2.55 Pain Relevance 0
Survivin is a member of the inhibitor of apoptosis protein (IAP) family, and has generated interest because of its increased expression in many human cancer cell lines [19].
Gene_expression (expression) of IAP associated with cancer and apoptosis
15) Confidence 0.31 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.28 Pain Relevance 0
Amylin, also termed islet amyloid polypeptide (IAPP) is a 37 amino acid polypeptide co-synthesized, co-packaged, and co-secreted by the islet beta cell with insulin.
Gene_expression (synthesized) of IAPP in beta cell associated with alzheimer's dementia
16) Confidence 0.30 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.52 Pain Relevance 0.09
Amylin, also termed islet amyloid polypeptide (IAPP) is a 37 amino acid polypeptide co-synthesized, co-packaged, and co-secreted by the islet beta cell with insulin.
Gene_expression (synthesized) of amyloid polypeptide in beta cell associated with alzheimer's dementia
17) Confidence 0.26 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.53 Pain Relevance 0.09
IAP samples were tested with
Gene_expression (samples) of IAP
18) Confidence 0.21 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.15 Pain Relevance 0
We also did not detect expression of Nkx6.1 or islet amyloid polypeptide, markers of mature pancreatic ?
Gene_expression (expression) of islet amyloid polypeptide associated with alzheimer's dementia
19) Confidence 0.12 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.25 Pain Relevance 0
Pramlintide is a synthetic analog of amylin.
Gene_expression (synthetic) of amylin
20) Confidence 0.03 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761191 Disease Relevance 0.79 Pain Relevance 0

General Comments

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