INT121850

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP8, BID) mitochondrion (CASP8, BID) cytoplasm (CASP8, BID)
peptidase activity (CASP8) nucleolus (CASP8) cytoskeleton (CASP8)
Anatomy Link Frequency
HL-60 2
cleavage 2
CASP8 (Homo sapiens)
BID (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 6 98.12 Very High Very High Very High
cytokine 1 69.84 Quite High
cINOD 3 58.24 Quite High
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 49 98.48 Very High Very High Very High
Death 8 86.36 High High
Leukemia 3 75.00 Quite High
Cancer 16 73.48 Quite High
Necrosis 2 66.20 Quite High
INFLAMMATION 1 52.08 Quite High
Hepatocellular Cancer 8 51.76 Quite High
Reprotox - General 1 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Solid Tumor 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest the sequential mechanism of diclofenac-induced apoptosis of HL-60 cells: ROS generation suppresses Akt activity, thereby activating caspase-8, which stimulates Bid cleavage and induces cytochrome c release and the activation of caspase-9 and-3 in a CsA-insensitive mechanism.
caspase-8 Positive_regulation (stimulates) of Protein_catabolism (cleavage) of Bid in HL-60 associated with apoptosis and diclofenac
1) Confidence 0.21 Published 2004 Journal Free Radic. Biol. Med. Section Abstract Doc Link 15451068 Disease Relevance 0.48 Pain Relevance 0.39
On the other hand, caspase-8 can induce Bid cleavage.
caspase-8 Positive_regulation (induce) of Protein_catabolism (cleavage) of Bid in cleavage
2) Confidence 0.02 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 1.33 Pain Relevance 0.03

General Comments

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