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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1, AKT1) cell proliferation (ROS1, AKT1) plasma membrane (ROS1, AKT1)
nucleoplasm (AKT1) transport (AKT1) small molecule metabolic process (AKT1)
Anatomy Link Frequency
HL-60 2
ROS1 (Homo sapiens)
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 6 99.30 Very High Very High Very High
cINOD 3 60.60 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 6 99.66 Very High Very High Very High
Leukemia 2 75.00 Quite High
INFLAMMATION 1 54.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest the sequential mechanism of diclofenac-induced apoptosis of HL-60 cells: ROS generation suppresses Akt activity, thereby activating caspase-8, which stimulates Bid cleavage and induces cytochrome c release and the activation of caspase-9 and-3 in a CsA-insensitive mechanism.
Gene_expression (generation) of ROS in HL-60 Negative_regulation (suppresses) of Akt associated with apoptosis and diclofenac
1) Confidence 0.25 Published 2004 Journal Free Radic. Biol. Med. Section Abstract Doc Link 15451068 Disease Relevance 0.49 Pain Relevance 0.40

General Comments

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