INT121860

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.92
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BID) mitochondrion (BID) cytoplasm (BID)
Anatomy Link Frequency
cleavage 1
BID (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 6 88.68 High High
cINOD 3 79.68 Quite High
metalloproteinase 28 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 29 100.00 Very High Very High Very High
Lung Cancer 136 91.84 High High
Cancer 56 80.40 Quite High
Leukemia 3 75.00 Quite High
INFLAMMATION 2 73.52 Quite High
Malignant Neoplastic Disease 11 50.00 Quite Low
Neurodegenerative Disease 1 45.04 Quite Low
Solid Tumor 5 28.64 Quite Low
Breast Cancer 1 21.76 Low Low
Metastasis 9 11.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclic AMP, an inducer of Akt phosphorylation, suppresses Akt inactivation, Bid cleavage, and DNA fragmentation.
Negative_regulation (inactivation) of Bid in cleavage
1) Confidence 0.29 Published 2004 Journal Free Radic. Biol. Med. Section Abstract Doc Link 15451068 Disease Relevance 0.53 Pain Relevance 0.38
A recent study similarly showed co-expression of the anti-apoptotic proteins Bcl-2, Bcl-XL and Mcl-1, with variable loss of expression of the anti-apoptotic Bad, Bak, Bax, Bid and Bim (O’Kane, 2006).
Spec (analyzed) Negative_regulation (loss) of Bid associated with apoptosis
2) Confidence 0.01 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.39 Pain Relevance 0

General Comments

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