INT121861

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.73
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BID) mitochondrion (BID) cytoplasm (BID)
Anatomy Link Frequency
cleavage 1
BID (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 4 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
diclofenac 6 99.08 Very High Very High Very High
cINOD 3 98.64 Very High Very High Very High
endometriosis 2 96.36 Very High Very High Very High
methotrexate 1 67.88 Quite High
rheumatoid arthritis 3 66.52 Quite High
Inflammation 2 65.80 Quite High
carbamazepine 1 53.44 Quite High
anesthesia 2 40.08 Quite Low
Disease Link Frequency Relevance Heat
Leukemia 4 99.96 Very High Very High Very High
Ocular Hypertension 3 99.60 Very High Very High Very High
Apoptosis 25 99.44 Very High Very High Very High
INFLAMMATION 3 97.92 Very High Very High Very High
Targeted Disruption 2 97.40 Very High Very High Very High
Glaucoma 29 97.28 Very High Very High Very High
Dysmenorrhea 2 97.00 Very High Very High Very High
Endometriosis (extended) 2 96.36 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 6 88.16 High High
Acute Promyelocytic Leukemia 1 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway.
Regulation (dependency) of Bid associated with leukemia, apoptosis and diclofenac
1) Confidence 0.31 Published 2004 Journal Free Radic. Biol. Med. Section Title Doc Link 15451068 Disease Relevance 0.62 Pain Relevance 0.45
The patient’s intraocular pressure has remained under control in mid 10’s on Betoptic-S 0.25% BID.
Regulation (control) of BID associated with ocular hypertension
2) Confidence 0.16 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698676 Disease Relevance 0.83 Pain Relevance 0.13
Additionally, it has been shown that HDACis have an effect on the cleavage of Bid and phosphorylation of Bad and Bim [31–33].
Regulation (effect) of Bid in cleavage
3) Confidence 0.13 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.09 Pain Relevance 0
Efficacy of gonadotropin-releasing hormone agonist and an extended-interval dosing regimen in the treatment of patients with adenomyosis and endometriosis.
Regulation (Efficacy) of agonist associated with endometriosis, dismenorea and agonist
4) Confidence 0.00 Published 2010 Journal Gynecol. Obstet. Invest. Section Title Doc Link 19923847 Disease Relevance 0.19 Pain Relevance 0.58

General Comments

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