INT121865

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 2.65
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
brain 4
hippocampus 4
LS1 2
forebrain 2
ACC neurons 2
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 106 100.00 Very High Very High Very High
Morphine 20 100.00 Very High Very High Very High
nMDA receptor 21 99.88 Very High Very High Very High
Hippocampus 30 99.80 Very High Very High Very High
Nucleus accumbens 141 99.12 Very High Very High Very High
addiction 4 99.02 Very High Very High Very High
Opioid 6 98.80 Very High Very High Very High
Eae 24 93.36 High High
mu opioid receptor 2 88.88 High High
Inflammation 3 74.28 Quite High
Disease Link Frequency Relevance Heat
Repression 134 100.00 Very High Very High Very High
Targeted Disruption 75 99.76 Very High Very High Very High
Cytomegalovirus Infection 6 99.20 Very High Very High Very High
Anxiety Disorder 188 99.00 Very High Very High Very High
INFLAMMATION 3 74.28 Quite High
Cognitive Disorder 6 65.04 Quite High
Congenital Anomalies 9 46.72 Quite Low
Sprains And Strains 3 45.16 Quite Low
Post-traumatic Stress Disorder 30 38.56 Quite Low
Shock 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined changes in expression of calcium/calmodulin-dependent protein kinase IV (CaMKIV) in the mouse brain following chronic morphine treatment.
Spec (examined) Regulation (changes) of Gene_expression (expression) of CaMKIV in brain associated with morphine
1) Confidence 0.54 Published 2005 Journal Neuroreport Section Abstract Doc Link 15931054 Disease Relevance 0 Pain Relevance 0.43
To assess the effects of dnCaMKIV expression on different aspects of anxiety-related behaviour and social behaviour animals were tested in a social interaction paradigm.
Regulation (effects) of Gene_expression (expression) of dnCaMKIV associated with anxiety disorder
2) Confidence 0.53 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.40 Pain Relevance 0.15
In this study, we examined changes in expression of calcium/calmodulin-dependent protein kinase IV (CaMKIV) in the mouse brain following chronic morphine treatment.
Spec (examined) Regulation (changes) of Gene_expression (expression) of protein kinase IV in brain associated with morphine
3) Confidence 0.39 Published 2005 Journal Neuroreport Section Abstract Doc Link 15931054 Disease Relevance 0 Pain Relevance 0.43
Expression of CaMKIV in ACC neurons of wild-type and CaMKIV transgenic mice
Regulation (type) of Gene_expression (Expression) of CaMKIV in ACC neurons associated with targeted disruption and anterior cingulate cortex
4) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.69 Pain Relevance 0.39
Next, the response of dnCaMKIV expressing animals on emotional stimuli was investigated in a battery of behavioural tests.


Spec (investigated) Regulation (response) of Gene_expression (expressing) of dnCaMKIV
5) Confidence 0.39 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.07 Pain Relevance 0.45
To better understand the role of CREB in opioids dependence and underlying signal pathways, we compared the effects of three ohmfentanyl stereoisomers ((-)-cis-(3R,4S,2'R) OMF (F9202), (+)-cis-(3R,4S,2'S) OMF (F9204), (-)-cis-(3S,4S,2'R) OMF (F9203)) and morphine on CREB phosphorylation and the expression of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) in hippocampus derived from mice which displayed conditioned place preference (CPP) behavior by Western blot, and immunohistochemistry analyses.
Regulation (effects) of Gene_expression (expression) of calmodulin-dependent protein kinase IV in hippocampus associated with addiction, hippocampus, opioid and morphine
6) Confidence 0.37 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.62
To better understand the role of CREB in opioids dependence and underlying signal pathways, we compared the effects of three ohmfentanyl stereoisomers ((-)-cis-(3R,4S,2'R) OMF (F9202), (+)-cis-(3R,4S,2'S) OMF (F9204), (-)-cis-(3S,4S,2'R) OMF (F9203)) and morphine on CREB phosphorylation and the expression of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) in hippocampus derived from mice which displayed conditioned place preference (CPP) behavior by Western blot, and immunohistochemistry analyses.
Regulation (effects) of Gene_expression (expression) of CaMKIV in hippocampus associated with addiction, hippocampus, opioid and morphine
7) Confidence 0.37 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.62
To test these hypotheses we used transgenic mice, over-expressing CaMKIV in the forebrain under the control of alpha CaMKII promoter [32,33].


Regulation (under) of Gene_expression (expressing) of CaMKIV in forebrain associated with targeted disruption
8) Confidence 0.24 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.20 Pain Relevance 0
We generated a rAAV vector expressing Flag-tagged dominant-negative CaMKIV under the control of the cytomegalovirus enhancer/chicken beta actin (CBA) promoter (Fig. 1A).
Regulation (under) of Gene_expression (expressing) of CaMKIV associated with cytomegalovirus infection
9) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.49 Pain Relevance 0.13
To roughly localize the RNA elements responsible for CaMK IV repression, we made several chimeric minigenes containing portions of E21 and portions of the constitutive Dup175 exon, and examined their response to CaMK IV.
Regulation (responsible) of Gene_expression (repression) of CaMK IV associated with repression
10) Confidence 0.23 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.44 Pain Relevance 0
Although the mutation M3–2 had no effect on CaMK IV repression, the mutation M3–3 totally abolished this response (Figure 3C, lanes 5 and 6), identifying critical nucleotides in the LS1 region.
Neg (no) Regulation (effect) of Gene_expression (repression) of CaMK IV in LS1 associated with repression
11) Confidence 0.23 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.37 Pain Relevance 0

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