INT121866

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 1.95
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
neurons 3
nucleus 3
neuronal 1
brain 1
crypt cells 1
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 73 99.42 Very High Very High Very High
Hippocampus 49 99.16 Very High Very High Very High
Calcitonin gene-related peptide 9 95.04 Very High Very High Very High
Opioid 31 91.56 High High
addiction 108 91.24 High High
antidepressant 90 90.08 High High
Trigeminal ganglion neurons 1 89.40 High High
bDMF 20 88.32 High High
noradrenaline 4 85.52 High High
Serotonin 23 83.84 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 16 97.56 Very High Very High Very High
Alzheimer's Dementia 40 96.88 Very High Very High Very High
Ganglion Cysts 1 89.08 High High
Disease 137 76.28 Quite High
Inflammatory Bowel Disease 1 75.08 Quite High
Enteritis 1 74.76 Quite High
Gastrointestinal Disease 3 74.00 Quite High
Headache 2 69.68 Quite High
Nociception 3 68.24 Quite High
Death 21 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such mutants have been described as carrying a hypomorphic CREB allele or as being haplodeficient in CREB [87], and a great deal of experimental work has been conducted using this model.


Localization (allele) of CREB
1) Confidence 0.73 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.16 Pain Relevance 0.04
Colocalization of phosphorylated CREB with calcium/calmodulin-dependent protein kinase IV in hippocampal neurons induced by ohmfentanyl stereoisomers.
Localization (Colocalization) of CREB in neurons
2) Confidence 0.69 Published 2004 Journal Brain Res. Section Title Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.54
F9203, which could not induce CPP, failed to increase the CREB phosphorylation and the colocalization of P-CREB with CaMKIV both in hippocampus from CPP mice and in cultured hippocampal neurons.
Localization (colocalization) of P-CREB in neurons associated with hippocampus
3) Confidence 0.69 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.58
The results of confocal fluorescence microscopy further demonstrated that the activated CREB (P-CREB) was colocalized with CaMKIV in nucleus.
Localization (colocalized) of CREB in nucleus
4) Confidence 0.64 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.63
The results of confocal fluorescence microscopy further demonstrated that the activated CREB (P-CREB) was colocalized with CaMKIV in nucleus.
Localization (colocalized) of P-CREB in nucleus
5) Confidence 0.64 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.63
More recently, spatiotemporal CREB deletion models have provided an illuminating and exciting way forward for the study of total central CREB deletion both temporally, and spatially within the brain, allowing investigators to better characterise precisely the contribution of CREB to the development and / or persistence of the addicted state.



Localization (deletion) of CREB in brain
6) Confidence 0.64 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0 Pain Relevance 0.12
CGRP activated Ca(2+)-calmodulin-dependent kinase II, which became localized to the perimembrane region and neuronal processes, a phenomenon already apparent after 30 min and accompanied by a parallel increase in cAMP-response element-binding protein (CREB) phosphorylation and nuclear translocation.
Localization (translocation) of CREB in neuronal associated with calcitonin gene-related peptide
7) Confidence 0.64 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.42 Pain Relevance 0.60
Moreover, we studied the effects of OMF and morphine on CREB phosphorylation and colocalization of phosphorylated CREB (P-CREB) with CaMKIV in cultured rat hippocampal neurons by Western blot, and confocal fluorescence microscopy analyses.
Localization (colocalization) of CREB in neurons associated with morphine
8) Confidence 0.60 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.65
In this study, we successfully cultured mouse intestinal crypt cells during a 24 h period and confirmed targeting of the CREB1 transcription factor, and CCNE1/CDK2 by miR-103 during cell cycle progression, implicating a role for miRNAs in intestinal growth.
Localization (targeting) of CREB1 in crypt cells
9) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0.22 Pain Relevance 0
Significant over-representation of TFBSs for transcription factor cyclic AMP-response element binding protein (CREB)/cyclic AMP response elements (3.9-fold, P = 6.8 × 10-3) was also found.
Localization (representation) of cyclic AMP-response element binding protein
10) Confidence 0.52 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.06
Significant over-representation of TFBSs for transcription factor cyclic AMP-response element binding protein (CREB)/cyclic AMP response elements (3.9-fold, P = 6.8 × 10-3) was also found.
Localization (representation) of CREB
11) Confidence 0.52 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.06
On the other hand dephosphorylated by hyper-activated CaN, CREB is not able to translocate into the nucleus to act as a transcription factor to regulate expression of different genes required for synaptic plasticity [19].
Localization (translocate) of CREB in nucleus
12) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.30 Pain Relevance 0
The authors speculate that inhibition of CREB translocation causes early synaptic dysfunction prior to the extracellular accumulation of amyloid peptide [136].
Localization (translocation) of CREB associated with alzheimer's dementia
13) Confidence 0.26 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 0.85 Pain Relevance 0.57

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox