INT121867

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.43
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
neuronal 2
neurons 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 4 99.16 Very High Very High Very High
Calcitonin gene-related peptide 9 96.06 Very High Very High Very High
Trigeminal ganglion neurons 1 91.44 High High
Morphine 5 90.32 High High
Opioid 3 82.56 Quite High
psychological dependence 1 81.92 Quite High
medulla 1 76.72 Quite High
Migraine 2 71.72 Quite High
Pain 3 67.60 Quite High
addiction 2 41.16 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 91.12 High High
Headache 2 71.72 Quite High
Nociception 1 70.28 Quite High
Pain 3 67.60 Quite High
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
F9203, which could not induce CPP, failed to increase the CREB phosphorylation and the colocalization of P-CREB with CaMKIV both in hippocampus from CPP mice and in cultured hippocampal neurons.
Neg (failed) Positive_regulation (increase) of Localization (colocalization) of P-CREB in neurons associated with hippocampus
1) Confidence 0.60 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.59
CGRP activated Ca(2+)-calmodulin-dependent kinase II, which became localized to the perimembrane region and neuronal processes, a phenomenon already apparent after 30 min and accompanied by a parallel increase in cAMP-response element-binding protein (CREB) phosphorylation and nuclear translocation.
Positive_regulation (increase) of Localization (translocation) of CREB in neuronal associated with calcitonin gene-related peptide
2) Confidence 0.55 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.43 Pain Relevance 0.62

General Comments

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