INT121869

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (Calm1)
Calm1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 99.86 Very High Very High Very High
Morphine 13 98.80 Very High Very High Very High
opioid receptor 1 95.00 High High
narcan 2 89.24 High High
Hippocampus 4 87.32 High High
mu opioid receptor 3 86.64 High High
Delta opioid receptors 1 83.28 Quite High
cerebral cortex 1 55.00 Quite High
addiction 2 53.88 Quite High
Opioid 3 53.44 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KN-62 (10 microM), an inhibitor of CaM kinases, prevented CREB phosphorylation induced by morphine, F9202, and F9204 without change of total CREB level.
Negative_regulation (inhibitor) of CaM associated with morphine
1) Confidence 0.57 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.79
In addition, both a calmodulin antagonist and a CaM II kinase inhibitor significantly suppressed the morphine-induced increase in DBI mRNA.
Negative_regulation (inhibitor) of CaM associated with antagonist and morphine
2) Confidence 0.42 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 1.04

General Comments

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