INT121870

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 24
Total Number 31
Disease Relevance 15.63
Pain Relevance 5.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
cingulate cortex 4
cortex 4
hippocampus 3
primary somatosensory cortex 2
caudate putamen 2
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 282 100.00 Very High Very High Very High
Morphine 15 99.98 Very High Very High Very High
Hippocampus 110 99.84 Very High Very High Very High
Anterior cingulate cortex 798 99.60 Very High Very High Very High
long-term potentiation 670 98.82 Very High Very High Very High
primary somatosensory cortex 2 98.52 Very High Very High Very High
mu opioid receptor 2 98.16 Very High Very High Very High
halothane 8 95.32 Very High Very High Very High
Calcium channel 16 94.16 High High
nMDA receptor 98 86.64 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 902 100.00 Very High Very High Very High
Anxiety Disorder 1098 99.96 Very High Very High Very High
Shock 168 99.96 Very High Very High Very High
Repression 134 90.28 High High
Sprains And Strains 48 86.32 High High
Post-traumatic Stress Disorder 66 78.64 Quite High
Cognitive Disorder 30 76.36 Quite High
Cytomegalovirus Infection 12 75.76 Quite High
Urological Neuroanatomy 18 71.12 Quite High
Schizophrenia 18 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, CaMKIV TG mice showed enhanced freezing behavior after receiving electrical footshocks during the conditioning when the footshock intensity was weak [37], suggesting that CaMKIV overexpression increases shock sensitivity.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CaMKIV associated with shock
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.49 Pain Relevance 0
First, synaptic proteins required for synaptic potentiation have been primed by overexpression of CaMKIV.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CaMKIV
2) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.41 Pain Relevance 0.50
In addition, mice with CaMKIV overexpression displayed enhanced freezing response in contextual fear conditioning [35].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CaMKIV associated with anxiety disorder
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.94 Pain Relevance 0
On the other hand, mice overexpressing CaMKIV (CaMKIV TG mice) show increased freezing behavior in a contextual fear conditioning task [37].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CaMKIV associated with anxiety disorder
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.65 Pain Relevance 0
m) containing the ACC from 6-8-week-old C57BL/6 male mice and mice with CaMKIV overexpression were prepared using standard methods [4,51].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CaMKIV associated with anterior cingulate cortex
5) Confidence 0.60 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.34 Pain Relevance 0.13
Especially, the nuclear/cytosolic ratio was significantly larger in the CaMKIV transgenic mice than in the wild-type mice, suggesting an enhanced expression of CaMKIV in the nuclei of CaMKIV transgenic mice.
Positive_regulation (enhanced) of Gene_expression (expression) of CaMKIV associated with targeted disruption
6) Confidence 0.60 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.36 Pain Relevance 0.46
Compared to controls, rAAV mediated dnCaMKIV expression in the Nac significantly reduced the total amount of social behaviour in the social interaction test (Student's t-test, p = 0.03).
Positive_regulation (mediated) of Gene_expression (expression) of dnCaMKIV
7) Confidence 0.60 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.49 Pain Relevance 0.10
Chronic treatment with morphine produced an increase in expression of CaMKIV and phosphorylated cAMP response element-binding protein (pCREB) in the CA3 region of the hippocampus, whereas a decrease in CaMKIV and pCREB expression was observed in the caudate putamen.
Positive_regulation (increase) of Gene_expression (expression) of CaMKIV in caudate putamen associated with hippocampus and morphine
8) Confidence 0.50 Published 2005 Journal Neuroreport Section Abstract Doc Link 15931054 Disease Relevance 0 Pain Relevance 0.55
Indeed, CaMKIV TG mice showed enhanced freezing behavior after receiving electrical footshocks during the conditioning when the footshock intensity was weak [37], suggesting that CaMKIV overexpression increases shock sensitivity.
Positive_regulation (increases) of Gene_expression (overexpression) of CaMKIV associated with shock
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.50 Pain Relevance 0
Our findings provide the first direct genetic evidence that enhancing CaMKIV expression in the forebrain enhances 4-7.5 Hz oscillations during trace fear conditioning and boosts slow delta oscillations during NREM sleep.
Positive_regulation (enhancing) of Gene_expression (expression) of CaMKIV in forebrain associated with anxiety disorder
10) Confidence 0.47 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.57 Pain Relevance 0
Overall, these results show that CaMKIV over-expression augments delta-related EEG oscillations in the sleep recording environment without impacting the time spent sleeping or the frequency of sleep.


Positive_regulation (over) of Gene_expression (expression) of CaMKIV
11) Confidence 0.47 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.15 Pain Relevance 0
Overall, these results show that CaMKIV over-expression augments delta-related EEG oscillations in the sleep recording environment without impacting the time spent sleeping or the frequency of sleep.


Positive_regulation (over) of Gene_expression (-) of CaMKIV
12) Confidence 0.47 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.15 Pain Relevance 0
Overall, these results show that CaMKIV over-expression augments delta-related EEG oscillations in the sleep recording environment without impacting the time spent sleeping or the frequency of sleep.


Positive_regulation (over) of Gene_expression (over) of CaMKIV
13) Confidence 0.47 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.15 Pain Relevance 0
An obvious increased expression of CaMKIV immunoreactivity in the nuclei was observed in CaMKIV transgenic mice (nuclei/cytosolic ratio of CaMKIV staining fluorescence intensity, 0.58 ± 0.02 in wild-type and 1.06 ± 0.03 in CaMKIV transgenic mice, P < 0.001).


Positive_regulation (increased) of Gene_expression (expression) of CaMKIV associated with targeted disruption
14) Confidence 0.46 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.74 Pain Relevance 0.30
These observations strongly suggest that overexpression of CaMKIV enhances early synaptic potentiation by promoting protein synthesis in ACC neurons.


Positive_regulation (overexpression) of Gene_expression (overexpression) of CaMKIV in ACC neurons associated with anterior cingulate cortex
15) Confidence 0.46 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.45 Pain Relevance 0.42
CaMKIV over-expression impacts slow delta oscillations
Positive_regulation (over) of Gene_expression (over) of CaMKIV
16) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.32 Pain Relevance 0.05
On the other hand, mice overexpressing CaMKIV (CaMKIV TG mice) show increased freezing behavior in a contextual fear conditioning task [37].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CaMKIV associated with anxiety disorder
17) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.65 Pain Relevance 0
As a result, the exon between XhoI and BstEII sites, which contained an initial codon for CaMKIV?
Positive_regulation (between) of Gene_expression (codon) of CaMKIV
18) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.52 Pain Relevance 0
Furthermore, expression of dnCaMKIV in the NAc significantly increased anxiety-like behaviour in the social interaction test (Fig. 3) (Student's t-test, p = 0.01).
Positive_regulation (increased) of Gene_expression (expression) of dnCaMKIV associated with nucleus accumbens and anxiety disorder
19) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.71 Pain Relevance 0.11
We show that increasing the expression of calcium/calmodulin dependent protein kinase IV (CaMKIV), a key nucleic protein kinase, selectively enhances 4-7.5 Hz oscillation power during trace fear learning and slow delta oscillations during subsequent sleep.
Positive_regulation (increasing) of Gene_expression (expression) of CaMKIV associated with anxiety disorder
20) Confidence 0.41 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC2888801 Disease Relevance 0.24 Pain Relevance 0

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