INT121872

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 12
Speculated 6
Reported most in Body
Documents 156
Total Number 173
Disease Relevance 70.47
Pain Relevance 21.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
ACC neurons 8
hippocampus 6
forebrain 6
brain 5
cortex 4
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 3601 100.00 Very High Very High Very High
nMDA receptor 276 99.88 Very High Very High Very High
Hippocampus 783 99.84 Very High Very High Very High
Nucleus accumbens 899 99.68 Very High Very High Very High
amygdala 117 99.68 Very High Very High Very High
Eae 442 99.60 Very High Very High Very High
Morphine 43 99.50 Very High Very High Very High
Pain 304 99.36 Very High Very High Very High
Acute pain 171 98.76 Very High Very High Very High
primary somatosensory cortex 5 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 2782 100.00 Very High Very High Very High
Repression 1208 100.00 Very High Very High Very High
Cognitive Disorder 295 99.92 Very High Very High Very High
Anxiety Disorder 9196 99.64 Very High Very High Very High
Post-traumatic Stress Disorder 221 99.60 Very High Very High Very High
Shock 2084 99.56 Very High Very High Very High
Pain 467 99.36 Very High Very High Very High
Cytomegalovirus Infection 40 98.96 Very High Very High Very High
Urological Neuroanatomy 256 98.66 Very High Very High Very High
Neuropathic Pain 10 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This should minimize type I errors (false positives) and produce a conservative estimation of the impact of CaMKIV over-expression.
Gene_expression (over) of CaMKIV
1) Confidence 0.78 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.09 Pain Relevance 0
Overall, these results show that CaMKIV over-expression augments delta-related EEG oscillations in the sleep recording environment without impacting the time spent sleeping or the frequency of sleep.


Gene_expression (over) of CaMKIV
2) Confidence 0.78 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.15 Pain Relevance 0
We found that CaMKIV over-expression enhances fear memory when studied ~24 hours after training.
Gene_expression (over) of CaMKIV associated with anxiety disorder
3) Confidence 0.78 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.27 Pain Relevance 0.22
Chronic treatment with morphine produced an increase in expression of CaMKIV and phosphorylated cAMP response element-binding protein (pCREB) in the CA3 region of the hippocampus, whereas a decrease in CaMKIV and pCREB expression was observed in the caudate putamen.
Gene_expression (expression) of CaMKIV in caudate putamen associated with hippocampus and morphine
4) Confidence 0.78 Published 2005 Journal Neuroreport Section Abstract Doc Link 15931054 Disease Relevance 0 Pain Relevance 0.55
Chronic treatment with morphine produced an increase in expression of CaMKIV and phosphorylated cAMP response element-binding protein (pCREB) in the CA3 region of the hippocampus, whereas a decrease in CaMKIV and pCREB expression was observed in the caudate putamen.
Gene_expression (expression) of CaMKIV in caudate putamen associated with hippocampus and morphine
5) Confidence 0.78 Published 2005 Journal Neuroreport Section Abstract Doc Link 15931054 Disease Relevance 0 Pain Relevance 0.57
Indeed, CaMKIV TG mice showed enhanced freezing behavior after receiving electrical footshocks during the conditioning when the footshock intensity was weak [37], suggesting that CaMKIV overexpression increases shock sensitivity.
Gene_expression (overexpression) of CaMKIV associated with shock
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.49 Pain Relevance 0
In the brain, CaMKIV is expressed in the hippocampus, amygdala, anterior cingulate cortex, somatosensory cortex, insular cortex and cerebellar granule cells.
Gene_expression (expressed) of CaMKIV in hippocampus associated with somatosensory cortex, hippocampus, anterior cingulate cortex and amygdala
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.06 Pain Relevance 0.20
Mice expressing dominant negative form of CaMKIV also exhibited deficit in cued and contextual fear conditioning test [32].
Neg (negative) Gene_expression (expressing) of CaMKIV associated with anxiety disorder
8) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.92 Pain Relevance 0
Among different Ca2+-dependent protein kinases, CaMKIV is detected predominantly in the nuclei of neurons [30], [31], and may therefore play a unique role in the phosphorylation of CREB and in the regulation of neuronal gene expression.
Gene_expression (detected) of CaMKIV in neuronal
9) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.18 Pain Relevance 0.16
First, synaptic proteins required for synaptic potentiation have been primed by overexpression of CaMKIV.
Gene_expression (overexpression) of CaMKIV
10) Confidence 0.77 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.41 Pain Relevance 0.50
Although CaMKIV is highly expressed in the ACC [19], little is known about how CaMKIV-induced protein synthesis contributes to the early-phase of synaptic potentiation in ACC neurons.
Gene_expression (expressed) of CaMKIV in ACC neurons associated with anterior cingulate cortex
11) Confidence 0.77 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.48 Pain Relevance 0.39
We performed immunostaining experiments to examine the expression of CaMKIV in the ACC neurons of wild-type and CaMKIV transgenic mice.
Spec (examine) Gene_expression (expression) of CaMKIV in ACC neurons associated with targeted disruption and anterior cingulate cortex
12) Confidence 0.77 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.70 Pain Relevance 0.33
CaMKIV is normally expressed during development and in the adult in many regions of the central nervous system and in the periphery [26,27].
Gene_expression (expressed) of CaMKIV in central nervous system associated with central nervous system
13) Confidence 0.77 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.53 Pain Relevance 0.23
Calcium-calmodulin-dependent protein kinase IV, which is widely expressed in central areas related to pain and memory, primarily contributes to injury-related fearful memory and emotional responses.
Gene_expression (expressed) of Calcium-calmodulin-dependent protein kinase IV in central areas associated with pain and injury
14) Confidence 0.76 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469048 Disease Relevance 0.96 Pain Relevance 0.55
Finally, CaMKIV over-expressed mice may have an alteration in their sleep homeostat.
Gene_expression (expressed) of CaMKIV
15) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.59 Pain Relevance 0
Additionally, REM sleep durations were not significantly different (F(1,14) = 0.244; p = 0.630, two-way ANOVA) between WT and CaMKIV over-expressed mice (Figure 7D).
Neg (not) Gene_expression (expressed) of CaMKIV
16) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.61 Pain Relevance 0
Since CaMKIV over-expression has been found to rescue memory impairment in aged mice [32], the enhanced slow wave delta power in the recording environment may reflect some degree of rescue of age-dependent slow wave oscillations.
Gene_expression (over) of CaMKIV associated with cognitive disorder
17) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.45 Pain Relevance 0
When EEG power was quantified in the recording environment, CaMKIV over-expressed mice showed an increase in slow delta oscillation power values, which persisted across the first 8 hours of the light period.
Gene_expression (expressed) of CaMKIV
18) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.63 Pain Relevance 0
Moreover, our results show that accentuation of trace fear learning and memory, whether by CaMKIV over-expression or through manipulation of the trace fear interval, produces prominent enhancement in 4-7.5 Hz power.
Gene_expression (over) of CaMKIV associated with anxiety disorder
19) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.54 Pain Relevance 0.03
CaMKIV over-expression impacts slow delta oscillations
Gene_expression (over) of CaMKIV
20) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.32 Pain Relevance 0.05

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