INT121873

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) mitochondrion (Creb1)
lyase activity (Car2) nucleus (Creb1) DNA binding (Creb1)
Anatomy Link Frequency
hippocampus 2
Creb1 (Mus musculus)
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 5 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
Hippocampus 4 97.88 Very High Very High Very High
psychological dependence 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To better understand the role of CREB in opioids dependence and underlying signal pathways, we compared the effects of three ohmfentanyl stereoisomers ((-)-cis-(3R,4S,2'R) OMF (F9202), (+)-cis-(3R,4S,2'S) OMF (F9204), (-)-cis-(3S,4S,2'R) OMF (F9203)) and morphine on CREB phosphorylation and the expression of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) in hippocampus derived from mice which displayed conditioned place preference (CPP) behavior by Western blot, and immunohistochemistry analyses.
CREB Regulation (role) of Phosphorylation (phosphorylation) of Ca2 in hippocampus associated with addiction, hippocampus, opioid and morphine
1) Confidence 0.10 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.62

General Comments

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