INT121884

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.63
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
respiratory 4
neuronal 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 8 100.00 Very High Very High Very High
qutenza 8 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 3 100.00 Very High Very High Very High
Neurotransmitter 1 100.00 Very High Very High Very High
Hyperesthesia 1 99.60 Very High Very High Very High
Inflammation 4 99.56 Very High Very High Very High
Hyperalgesia 3 98.88 Very High Very High Very High
diabetic neuropathy 4 98.36 Very High Very High Very High
opioid receptor 84 96.08 Very High Very High Very High
Calcium channel 1 91.40 High High
Disease Link Frequency Relevance Heat
Hyperaesthesia 1 99.60 Very High Very High Very High
INFLAMMATION 4 99.56 Very High Very High Very High
Hyperalgesia 4 98.88 Very High Very High Very High
Diabetic Neuropathy 4 98.36 Very High Very High Very High
Peripheral Neuropathy 1 97.72 Very High Very High Very High
Nociception 9 89.20 High High
Diabetes Mellitus 9 86.16 High High
Pain 5 74.08 Quite High
Urological Neuroanatomy 18 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ca2+-CaM then increases and activates CaMKII (13) that, in turn, acts on nNOS Ser847 to reduce Ca2+-CaM binding and NO production (14).
Regulation (acts) of nNOS Binding (binding) of
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.42
Besides alteration in the levels of neurotransmitter, alteration in the neuronal nitric oxide synthase (nNOS) is a key factor in the pathogenesis of diabetic neuropathy.
Regulation (alteration) of nNOS Binding (alteration) of in neuronal associated with neurotransmitter, diabetic neuropathy and neuronal nitric oxide synthase
2) Confidence 0.25 Published 2004 Journal Pharmacology Section Abstract Doc Link 15452368 Disease Relevance 1.44 Pain Relevance 0.71
We investigated the effects of substance P (SP) and neurokinin A (NKA) infusion and acute stimulation of capsaicin-sensitive sensory nerves fibers (CAP) on lung recruitment of neuronal nitric oxide synthase (nNOS)-positive inflammatory and respiratory epithelial (RE) cells in guinea-pigs.
Spec (investigated) Regulation (effects) of nNOS Binding (recruitment) of in respiratory associated with inflammation, qutenza, neuronal nitric oxide synthase and substance p
3) Confidence 0.24 Published 2008 Journal Respir Physiol Neurobiol Section Abstract Doc Link 17897889 Disease Relevance 0.10 Pain Relevance 0.51
We investigated the effects of substance P (SP) and neurokinin A (NKA) infusion and acute stimulation of capsaicin-sensitive sensory nerves fibers (CAP) on lung recruitment of neuronal nitric oxide synthase (nNOS)-positive inflammatory and respiratory epithelial (RE) cells in guinea-pigs.
Spec (investigated) Regulation (effects) of neuronal nitric oxide synthase Binding (recruitment) of in respiratory associated with inflammation, qutenza, neuronal nitric oxide synthase and substance p
4) Confidence 0.24 Published 2008 Journal Respir Physiol Neurobiol Section Abstract Doc Link 17897889 Disease Relevance 0.10 Pain Relevance 0.51

General Comments

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