INT12189

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Context Info
Confidence 0.73
First Reported 1992
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.63
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cellular_component (Gpt) biological_process (Gpt)
cytoplasm (Gpt)
Anatomy Link Frequency
liver 3
blood 2
plasma 1
tubes 1
Gpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 14 100.00 Very High Very High Very High
Bile 4 99.98 Very High Very High Very High
Paracetamol 171 97.36 Very High Very High Very High
ketamine 1 82.84 Quite High
ischemia 59 79.00 Quite High
anesthesia 2 52.96 Quite High
Potency 1 29.92 Quite Low
cva 9 11.04 Low Low
Inflammation 14 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 56 100.00 Very High Very High Very High
Injury 70 99.92 Very High Very High Very High
Infarction 1 99.20 Very High Very High Very High
Hepatitis Virus Infection 1 98.00 Very High Very High Very High
Decapitation 4 96.20 Very High Very High Very High
Necrosis 15 90.92 High High
Overdose 7 86.76 High High
Stress 25 86.24 High High
Body Weight 19 86.00 High High
Parkinson's Disease 3 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hepatotoxicity was evident from the nearly complete interruption of bile secretion, a marked release of enzymes [glutamate-pyruvate transaminase (GPT), lactate dehydrogenase (LDH)] in the perfusate, a depletion of hepatic glutathione and an accumulation of calcium in the liver.
Localization (secretion) of GPT in liver associated with glutamate, bile and hepatotoxicity
1) Confidence 0.73 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1632830 Disease Relevance 0.45 Pain Relevance 0.64
Serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) were estimated by International Federation of Clinical Chemistry.15 Serum bilirubin was estimated by Diazo method.16
Localization (Serum) of alanine aminotransferase
2) Confidence 0.73 Published 2008 Journal Indian Journal of Nephrology Section Body Doc Link PMC2813123 Disease Relevance 0.24 Pain Relevance 0.05
Hepatotoxicity was evident from the nearly complete interruption of bile secretion, a marked release of enzymes [glutamate-pyruvate transaminase (GPT), lactate dehydrogenase (LDH)] in the perfusate, a depletion of hepatic glutathione and an accumulation of calcium in the liver.
Localization (release) of GPT in liver associated with glutamate, bile and hepatotoxicity
3) Confidence 0.64 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1632830 Disease Relevance 0.45 Pain Relevance 0.64
LDH and GPT release, on the other hand, was elevated at 2 and 5 g/L and calcium accumulation occurred at 5 g/L paracetamol only.
Localization (release) of GPT associated with paracetamol
4) Confidence 0.64 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1632830 Disease Relevance 0.47 Pain Relevance 0.95
Measurement of plasma GPT and GOT
Localization (Measurement) of plasma GPT in plasma
5) Confidence 0.59 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.17 Pain Relevance 0.29
rpm for 20 minutes, and blood sera were then collected and stored at 4°C prior immediate determination of glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), alkaline phosphatase (ALP), acid phosphatase (ACP), total protein, total albumin, creatinine, urea, and uric acid.
Spec (determination) Localization (determination) of GPT in blood
6) Confidence 0.55 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0 Pain Relevance 0
rpm for 20 minutes, and blood sera were then collected and stored at 4°C prior immediate determination of glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), alkaline phosphatase (ALP), acid phosphatase (ACP), total protein, total albumin, creatinine, urea, and uric acid.
Spec (determination) Localization (determination) of glutamic pyruvic acid transaminase in blood
7) Confidence 0.55 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864892 Disease Relevance 0 Pain Relevance 0
GPT catalyzes the conversion of alanine to pyruvate and glutamate, and is released in a similar manner.
Localization (released) of GPT associated with glutamate
8) Confidence 0.42 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900060 Disease Relevance 1.16 Pain Relevance 0.40
Supernatants were transferred into fresh tubes for evaluation of concentration of glutamic-oxaloacetic transaminase (AST), glutamic pyruvic transaminase (ALT), the ratio of AST compare ALT (S/L), total protein (TP), albumin (ALB), globulin (GLB), the ratio of ALB compare GLB (A/G), phosphocreatine kinase (CK), lactate dehydrogenase (LDH), urea nitrogen (BUN) and creatinine (CRE) through automatic biochemistry analyzer(abbott, USA).


Localization (oxaloacetic) of glutamic pyruvic transaminase in tubes
9) Confidence 0.32 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 0.23 Pain Relevance 0.04
The plasma fractions were analyzed for indices of liver damage (alanine transaminase, aspartate transaminase, lactate dehydrogenase), levels of malondialdehyde (MDA), reduced (GSH) and oxidized (GSSG) glutathione, and activities of glutathione reductase (GR), glutathione S-transferase (GST) and ?
Localization (damage) of alanine transaminase in liver associated with hepatotoxicity
10) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.47 Pain Relevance 0.91

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