INT12190

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Context Info
Confidence 0.21
First Reported 1992
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.98
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
liver 2
Got1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 1 100.00 Very High Very High Very High
Glutamate 1 100.00 Very High Very High Very High
Paracetamol 14 93.92 High High
Inflammation 1 70.08 Quite High
cINOD 2 62.52 Quite High
Disease Link Frequency Relevance Heat
Gallstones 2 99.84 Very High Very High Very High
Hepatotoxicity 6 99.24 Very High Very High Very High
Parkinson's Disease 1 84.80 Quite High
Liver Disease 3 73.68 Quite High
Toxicity 1 72.28 Quite High
INFLAMMATION 2 62.00 Quite High
Hypoxia 2 25.00 Low Low
Injury 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hepatotoxicity was evident from the nearly complete interruption of bile secretion, a marked release of enzymes [glutamate-pyruvate transaminase (GPT), lactate dehydrogenase (LDH)] in the perfusate, a depletion of hepatic glutathione and an accumulation of calcium in the liver.
Negative_regulation (interruption) of Localization (secretion) of transaminase in liver associated with glutamate, bile and hepatotoxicity
1) Confidence 0.21 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1632830 Disease Relevance 0.45 Pain Relevance 0.64
A conventional dose of naproxen similarly prevented transaminase release.
Negative_regulation (prevented) of Localization (release) of transaminase
2) Confidence 0.11 Published 1997 Journal J Drug Target Section Abstract Doc Link 9169987 Disease Relevance 0.53 Pain Relevance 0.16

General Comments

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