INT121909

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.06
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

FAIM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
MU agonist 4 99.32 Very High Very High Very High
Opioid 38 97.64 Very High Very High Very High
Buprenorphine 176 97.24 Very High Very High Very High
agonist 15 92.72 High High
cytokine 12 92.28 High High
withdrawal 2 92.00 High High
Inflammation 13 90.84 High High
mu opioid receptor 3 89.32 High High
Inflammatory mediators 1 89.28 High High
Analgesic 27 84.92 Quite High
Disease Link Frequency Relevance Heat
Depression 51 95.96 Very High Very High Very High
Substance Withdrawal Syndrome 2 92.36 High High
INFLAMMATION 19 90.84 High High
Disease Susceptibility 4 85.04 High High
Pain 79 50.00 Quite Low
Cognitive Disorder 7 49.52 Quite Low
Neuropathic Pain 15 14.32 Low Low
Sleep Disorders 9 11.12 Low Low
Renal Insufficiency 2 10.60 Low Low
Respiratory Failure 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor.
Regulation (targeting) of mu receptor
1) Confidence 0.22 Published 2004 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 15454210 Disease Relevance 0 Pain Relevance 0.10
By affecting the mu receptor, reserve buprenrophine can enable the switch from another opioid to buprenorphine.
Regulation (affecting) of mu receptor associated with opioid and buprenorphine
2) Confidence 0.21 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682375 Disease Relevance 0.09 Pain Relevance 2.15
In addition, the block 2 extends further from the IL24 gene in 3' direction and includes the genes FAIM3, PIGR, and FCAMR (HapMap, genome build 35), that could also be affected by alternative haplotypes.
Regulation (affected) of FAIM3
3) Confidence 0.11 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0.97 Pain Relevance 0.17

General Comments

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