INT12191

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 35
Total Number 35
Disease Relevance 13.71
Pain Relevance 12.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
plasma 4
hepatocytes 4
neurons 4
heart 4
RAM 3
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 344 100.00 Very High Very High Very High
Paracetamol 57 100.00 Very High Very High Very High
Bile 2 100.00 Very High Very High Very High
narcan 10 99.68 Very High Very High Very High
Potency 38 99.66 Very High Very High Very High
local anesthetic 17 99.66 Very High Very High Very High
lidocaine 16 99.42 Very High Very High Very High
tetrodotoxin 5 99.20 Very High Very High Very High
ischemia 99 99.12 Very High Very High Very High
antagonist 64 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 221 100.00 Very High Very High Very High
Contracture 2 100.00 Very High Very High Very High
Apoptosis 226 99.92 Very High Very High Very High
Toxicity 38 99.62 Very High Very High Very High
Shock 4 99.60 Very High Very High Very High
Injury 98 99.38 Very High Very High Very High
Hepatotoxicity 5 99.24 Very High Very High Very High
Cv Unclassified Under Development 85 99.12 Very High Very High Very High
Heart Rate Under Development 6 98.38 Very High Very High Very High
Myeloid Leukemia 50 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this model, SQ 32,547 was protective because it significantly reduced contracture formation and lactate dehydrogenase (LDH) release.
Negative_regulation (reduced) of Localization (release) of LDH associated with contracture
1) Confidence 0.59 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7475054 Disease Relevance 0.25 Pain Relevance 0.22
A good correlation was found between the potency of the drugs to inhibit released LDH induced by 30 microM veratridine in neuronal cultures and their binding affinity for the batrachotoxin binding site of Na+ channels in rat cortex synaptosomal preparation.
Negative_regulation (inhibit) of Localization (released) of LDH in cortex associated with potency
2) Confidence 0.59 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.14 Pain Relevance 0.48
Ca++ antagonists, nonselective for slow Ca++ channels (flunarizine, cinnarizine, lidoflazine, prenylamine and bepridil) inhibited veratridine-induced release of LDH with IC50 values between 0.11 and 0.47 microM.
Negative_regulation (inhibited) of Localization (release) of LDH associated with antagonist
3) Confidence 0.59 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.08 Pain Relevance 0.39
Tested local anesthetics were incomplete inhibitors of veratridine-induced release of LDH.
Negative_regulation (inhibitors) of Localization (release) of LDH associated with local anesthetic
4) Confidence 0.59 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.14 Pain Relevance 0.49
The release of LDH occurred gradually and could be completely prevented by 2 mM ethylene glycol bis (beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid, 0.1 microM tetrodotoxin, and 1 microM flunarizine.
Negative_regulation (prevented) of Localization (release) of LDH associated with tetrodotoxin
5) Confidence 0.58 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2554110 Disease Relevance 0.22 Pain Relevance 0.27
Veratridine-induced LDH release can be inhibited by 100 microM riluzole (-90% and by tetrodotoxin (1 microM).
Negative_regulation (inhibited) of Localization (release) of LDH associated with tetrodotoxin
6) Confidence 0.57 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7824190 Disease Relevance 0.32 Pain Relevance 0.18
N-Acetylcysteine (4 mM) reduced the degree of LDH release by AAP (4 to 16 mM) but was not protective against cell killing by AFB1, although it slightly reduced the percentage of hepatocytes with segmental cytoplasmic contraction at 6 hr.
Negative_regulation (reduced) of Localization (release) of LDH in hepatocytes associated with paracetamol
7) Confidence 0.54 Published 1986 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3088775 Disease Relevance 0.17 Pain Relevance 0.44
The suppression of LDH release was observed even when isoflurane was administered during the reperfusion period, but not when it was administered only during ischemia.
Negative_regulation (suppression) of Localization (release) of LDH
8) Confidence 0.43 Published 1996 Journal Acta Anaesthesiol Scand Section Body Doc Link 8986190 Disease Relevance 0.11 Pain Relevance 0
Volatile anesthetics also significantly attenuated LDH release during reperfusion.
Negative_regulation (attenuated) of Localization (release) of LDH
9) Confidence 0.43 Published 1996 Journal Acta Anaesthesiol Scand Section Body Doc Link 8986190 Disease Relevance 0.11 Pain Relevance 0
Ca++ antagonists selective for slow Ca++ channels were less potent and inhibited veratridine-induced release of LDH at concentrations in the following order of potency: nicardipine greater than gallopamil and verapamil greater than niludipine greater than nitrendipine greater than nifedipine greater than nimodipine greater than diltiazem.
Negative_regulation (inhibited) of Localization (release) of LDH associated with antagonist and potency
10) Confidence 0.43 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.08 Pain Relevance 0.41
In this model, SQ 32,547 was protective because it significantly reduced contracture formation and lactate dehydrogenase (LDH) release.
Negative_regulation (reduced) of Localization (release) of lactate dehydrogenase associated with contracture
11) Confidence 0.43 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7475054 Disease Relevance 0.25 Pain Relevance 0.22
Nifedipine treatment prior to APAP exposure, partially prevented LDH release, the plasma membrane blebbing, and thereby the loss of viability.
Negative_regulation (loss) of Localization (release) of LDH in plasma associated with paracetamol
12) Confidence 0.42 Published 1995 Journal Drug Chem Toxicol Section Abstract Doc Link 7497906 Disease Relevance 0.05 Pain Relevance 0.61
Nifedipine treatment prior to APAP exposure, partially prevented LDH release, the plasma membrane blebbing, and thereby the loss of viability.
Negative_regulation (prevented) of Localization (release) of LDH in plasma associated with paracetamol
13) Confidence 0.42 Published 1995 Journal Drug Chem Toxicol Section Abstract Doc Link 7497906 Disease Relevance 0.05 Pain Relevance 0.61
Propranolol caused a significant decrease of LDH retention in the fraction of attached cells (> or = 5 x 10(-5) M, RAM and RTII; > or = 5 x 10(-4) M, HAM and A549).
Negative_regulation (decrease) of Localization (retention) of LDH in RAM
14) Confidence 0.42 Published 2003 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 14571279 Disease Relevance 0.06 Pain Relevance 0
Riluzole inhibited the NMDA-induced LDH release in the presence of tetrodotoxin.
Negative_regulation (inhibited) of Localization (release) of LDH associated with tetrodotoxin
15) Confidence 0.42 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7824190 Disease Relevance 0.34 Pain Relevance 0.19
RESULTS: Left ventricular developed pressure percentage did not differ between groups, whereas lactate dehydrogenase release was significantly reduced in MORPH compared with CONT hearts.
Negative_regulation (reduced) of Localization (release) of lactate dehydrogenase in hearts
16) Confidence 0.41 Published 2009 Journal Eur J Anaesthesiol Section Body Doc Link 19359990 Disease Relevance 0.14 Pain Relevance 0
These effects of 44Bu and lidocaine closely correlated with the reduction in the infarct size and lactate dehydrogenase release.
Negative_regulation (reduction) of Localization (release) of lactate dehydrogenase associated with lidocaine
17) Confidence 0.38 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20450906 Disease Relevance 0.74 Pain Relevance 0.79
To investigate these 2 microRNAs in more detail, we measured their expression, WST-1 for mitochondrial function and LDH release for cell collapse in primary cultured hepatocytes exposed to several concentrations of acetaminophen for 3 hr.
Negative_regulation (measured) of Localization (release) of LDH in hepatocytes associated with paracetamol and shock
18) Confidence 0.37 Published 2007 Journal J Toxicol Sci Section Abstract Doc Link 17965554 Disease Relevance 0.32 Pain Relevance 0.34
At a concentration of 50 microM added simultaneously with paracetamol, ebselen prevented paracetamol-induced leakage of lactate dehydrogenase (LDH) almost completely and lipid peroxidation (LPO) and depletion of glutathione (GSH) substantially.
Negative_regulation (prevented) of Localization (leakage) of LDH associated with paracetamol
19) Confidence 0.36 Published 1994 Journal Biochem. Pharmacol. Section Abstract Doc Link 7980628 Disease Relevance 0.17 Pain Relevance 0.75
Hepatotoxicity was evident from the nearly complete interruption of bile secretion, a marked release of enzymes [glutamate-pyruvate transaminase (GPT), lactate dehydrogenase (LDH)] in the perfusate, a depletion of hepatic glutathione and an accumulation of calcium in the liver.
Negative_regulation (interruption) of Localization (secretion) of LDH in liver associated with glutamate, bile and hepatotoxicity
20) Confidence 0.35 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1632830 Disease Relevance 0.45 Pain Relevance 0.65

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