INT121937

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.48
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gorasp2)
Anatomy Link Frequency
spinal 2
Gorasp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 8 99.52 Very High Very High Very High
intrathecal 1 97.92 Very High Very High Very High
antagonist 2 84.24 Quite High
Dorsal horn 1 83.48 Quite High
Spinal cord 1 83.00 Quite High
Peripheral nerve injury 2 75.00 Quite High
dexamethasone 1 71.84 Quite High
agonist 1 71.28 Quite High
allodynia 2 68.16 Quite High
Thermal hyperalgesia 2 67.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.62 Very High Very High Very High
Neuropathic Pain 10 99.52 Very High Very High Very High
Nervous System Injury 10 98.20 Very High Very High Very High
Hyperalgesia 2 67.16 Quite High
Nociception 1 48.20 Quite Low
INFLAMMATION 1 45.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the expression of neuronal GR after CCI was mediated in part through an elevated spinal level of interleukin-6 (IL-6) and protein kinase Cgamma (PKCgamma), because intrathecal treatment with an IL-6 antiserum, a PKC inhibitor (cheryrithrine), or PKCgamma knock-out substantially reduced the expression of neuronal GRs as well as neuropathic pain behaviors after CCI.
Negative_regulation (reduced) of Gene_expression (expression) of GRs in spinal associated with targeted disruption, nervous system injury, neuropathic pain and intrathecal
1) Confidence 0.14 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15456833 Disease Relevance 1.48 Pain Relevance 1.17

General Comments

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