INT121938

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.28
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gorasp2)
Anatomy Link Frequency
neuronal 1
spinal 1
spinal cord dorsal horn 1
Gorasp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 16 99.52 Very High Very High Very High
Spinal cord 2 99.12 Very High Very High Very High
Dorsal horn 2 98.64 Very High Very High Very High
intrathecal 2 97.68 Very High Very High Very High
dexamethasone 2 91.20 High High
agonist 2 90.64 High High
allodynia 4 87.52 High High
Thermal hyperalgesia 4 86.52 High High
antagonist 4 84.24 Quite High
Peripheral nerve injury 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 20 99.52 Very High Very High Very High
Targeted Disruption 2 99.38 Very High Very High Very High
Nervous System Injury 20 99.08 Very High Very High Very High
Hyperalgesia 4 86.52 High High
Nociception 2 67.56 Quite High
INFLAMMATION 2 64.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting was used to examine the expression of GRs within the spinal cord dorsal horn.
Spec (examine) Gene_expression (expression) of GRs in spinal cord dorsal horn
1) Confidence 0.30 Published 2005 Journal Anesthesiology Section Body Doc Link 15791114 Disease Relevance 0 Pain Relevance 0
Moreover, the expression of neuronal GR after CCI was mediated in part through an elevated spinal level of interleukin-6 (IL-6) and protein kinase Cgamma (PKCgamma), because intrathecal treatment with an IL-6 antiserum, a PKC inhibitor (cheryrithrine), or PKCgamma knock-out substantially reduced the expression of neuronal GRs as well as neuropathic pain behaviors after CCI.
Gene_expression (expression) of GRs in spinal associated with targeted disruption, nervous system injury, neuropathic pain and intrathecal
2) Confidence 0.20 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15456833 Disease Relevance 1.47 Pain Relevance 1.17
Mechanistically, CCI induced a time-dependent and region-specific expression of neuronal GRs primarily within the spinal cord dorsal horn ipsilateral to nerve injury, which showed a time course parallel to that of the development of neuropathic pain behaviors.
Gene_expression (expression) of GRs in neuronal associated with nervous system injury, neuropathic pain, dorsal horn and spinal cord
3) Confidence 0.20 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15456833 Disease Relevance 1.81 Pain Relevance 1.21

General Comments

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