INT121942

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 32
Disease Relevance 15.69
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Anatomy Link Frequency
CAR 4
bowel 1
bile 1
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 1209 99.36 Very High Very High Very High
Inflammation 527 99.04 Very High Very High Very High
Paracetamol 6 99.00 Very High Very High Very High
Crohn's disease 186 98.66 Very High Very High Very High
antagonist 217 95.76 Very High Very High Very High
Versed 31 94.64 High High
agonist 279 93.56 High High
anticonvulsant 31 88.04 High High
antidepressant 93 81.64 Quite High
Inflammatory stimuli 31 80.60 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 63 99.92 Very High Very High Very High
Inflammatory Bowel Disease 992 99.82 Very High Very High Very High
Disease 310 98.66 Very High Very High Very High
Osteogenic Sarcomas 155 98.44 Very High Very High Very High
Injury 1 96.72 Very High Very High Very High
Increased Venous Pressure Under Development 31 95.04 Very High Very High Very High
Hyperlipidemia 93 94.24 High High
Osteoporosis 217 93.84 High High
Necrosis 32 93.68 High High
INFLAMMATION 372 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, they also reported that SXR was associated with condensed mitotic DNA during mitosis.
SXR Binding (associated) of
1) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0
Their data also support the association of the SXR locus with extensive UC and the interaction between SXR and MDR1 genes.
SXR Binding (association) of associated with inflammatory bowel disease
2) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.71 Pain Relevance 0.24
Larger studies in other populations may help to clarify the association between SXR and susceptibility to IBD.
SXR Binding (association) of associated with inflammatory bowel disease
3) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.63 Pain Relevance 0.20
Vitamin K2 bound to and activated SXR and induced expression of the SXR target genes in osteosarcoma cells.
SXR Binding (bound) of associated with osteogenic sarcomas
4) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.61 Pain Relevance 0
In accord with these findings, several clinical studies have found that the SXR gene is associated with susceptibility to inflammatory bowel disease [Dring et al., 2006; Martinez et al., 2007].
SXR gene Binding (associated) of in bowel associated with inflammation
5) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.59 Pain Relevance 0.23
Ho et al. performed a genome-wide association study in total of 387 UC and 328 CD patients, together with 338 healthy controls and did not find any association between SXR and IBD.
SXR Neg (not) Binding (association) of associated with inflammatory bowel disease and crohn's disease
6) Confidence 0.39 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.94 Pain Relevance 0.29
Although it shares the same overall arrangement of its functional domains with other nuclear receptors, in contrast to most other receptors SXR can bind structurally diverse ligands.
SXR Binding (bind) of
7) Confidence 0.39 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
Pretreatment with the PXR activator, pregnenolone 16alpha-carbonitrile (PCN), markedly enhanced APAP-induced hepatic injury, as revealed by increased serum ALT levels and hepatic centrilobular necrosis, in wild-type but not in PXR-null mice.
PXR activator Binding (Pretreatment) of associated with necrosis, paracetamol and injury
8) Confidence 0.37 Published 2004 Journal Toxicol. Sci. Section Abstract Doc Link 15456926 Disease Relevance 0.43 Pain Relevance 0.52
Here we discuss the crosstalk between SXR and CAR, FXR and VDR, all of which appear to be important for xenobiotic, bile acid, or vitamin D metabolism and disposition.
SXR Binding (crosstalk) of in CAR associated with bile
9) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.07
Two groups recently revealed a crosstalk between SXR and NF-?
SXR Binding (crosstalk) of
10) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.62 Pain Relevance 0.27
However, a detailed study comparing the activity of all SXR SNPs toward ligand activation and the potential interactions between these SNPs and the ability of SXR to modulate the activity of CAR and other transcription factors remains to be performed.
SXR Binding (interactions) of in CAR
11) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.18 Pain Relevance 0.07
Numerous compounds, many of which are EDCs, can affect the activity of SXR.
SXR Binding (activity) of
12) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0.14
These include interfering with thyroid and retinoid receptor function, by interfering with activities of other nuclear hormone receptors such as SXR, CAR and PPAR?
SXR Binding (activities) of in CAR
13) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
B p65 disrupted binding of the SXR-RXR complex to its binding motif.
SXR Binding (complex) of
14) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.45 Pain Relevance 0.13
Future studies that investigate the potential mechanisms of molecular recognition by SXR and CYP3A4 may help us to understand the complex of xenobiotic metabolism regulated by SXR-CYP3A4 axis.
SXR Binding (recognition) of
15) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
Interestingly, the SXR ligand-binding domain also contains a consensus SUMOylation site, but it is currently unknown whether SUMOylation of SXR is involved in transrepression of NF-?
SXR Binding (ligand) of
16) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.77 Pain Relevance 0.18
Although there is no obvious causal link known between microtubule stabilization and SXR activation, the association suggests that SXR itself may be linked with the cytotoxic effects of these drugs [Mani et al., 2005].
SXR Binding (linked) of
17) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.37 Pain Relevance 0.03
Their data also support the association of the SXR locus with extensive UC and the interaction between SXR and MDR1 genes.
SXR Binding (interaction) of associated with inflammatory bowel disease
18) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.68 Pain Relevance 0.21
These include interfering with thyroid and retinoid receptor function, by interfering with activities of other nuclear hormone receptors such as SXR, CAR and PPAR?
SXR Binding (interfering) of in CAR
19) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
It can also promote recruitment of the coactivator SRC-1 to SXR and displaces radiolabeled ligand bound to SXR, suggesting a direct interaction with the receptor.
SXR Binding (bound) of
20) Confidence 0.34 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.53 Pain Relevance 0.11

General Comments

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